How Mouse Macrophages Sense What Is Going On.
How Mouse Macrophages Sense What Is Going On.
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DOI：
10.3389/fimmu.2016.00204
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发表时间：
2016
影响因子：
7.3
通讯作者：
Ting JP
中科院分区：
文献类型：
--
作者：
Ley K;Pramod AB;Croft M;Ravichandran KS;Ting JP
巨噬细胞是先天免疫和获得性免疫的中枢细胞。在几乎所有的组织和器官中，巨噬细胞都是第一个感觉到麻烦并对干扰做出反应的细胞，几乎没有例外。它们感知周围环境，抑制或杀死病原体，吸收凋亡和坏死的细胞，修复组织损伤，并将抗原呈递给T细胞。虽然巨噬细胞的来源(卵黄囊与单核细胞来源)和表型(功能、基因表达谱、表面标记)在不同组织之间不同，但它们有许多共同的受体，这些受体是一个或几个分子物种所特有的。在这里，我们回顾了近200个关键的巨噬细胞受体的表达和功能，这些受体帮助巨噬细胞感知正在发生的事情，包括病原体衍生的分子、周围组织细胞的状态、凋亡和坏死性细胞死亡、抗体和免疫复合体、改变的自身分子、细胞外基质成分和包括趋化因子在内的细胞因子。
Macrophages are central to both innate and adaptive immunity. With few exceptions, macrophages are the first cells that sense trouble and respond to disturbances in almost all tissues and organs. They sense their environment, inhibit or kill pathogens, take up apoptotic and necrotic cells, heal tissue damage, and present antigens to T cells. Although the origins (yolk sac versus monocyte-derived) and phenotypes (functions, gene expression profiles, surface markers) of macrophages vary between tissues, they have many receptors in common that are specific to one or a few molecular species. Here, we review the expression and function of almost 200 key macrophage receptors that help the macrophages sense what is going on, including pathogen-derived molecules, the state of the surrounding tissue cells, apoptotic and necrotic cell death, antibodies and immune complexes, altered self molecules, extracellular matrix components, and cytokines, including chemokines.