Prenatal behavior of the C57BL/6J mouse: a promising model for human fetal movement during early to mid-gestation.
Prenatal behavior of the C57BL/6J mouse: a promising model for human fetal movement during early to mid-gestation.
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C57BL/6J 小鼠的产前行为：妊娠早期至中期人类胎儿运动的有前景的模型。
DOI：
10.1002/dev.20348
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发表时间：
2009
影响因子：
2.2
通讯作者：
Ronca,AprilE
中科院分区：
文献类型：
--
作者：
Kleven,GaleA;Ronca,AprilE
对基因改变小鼠的胎儿神经行为发育的研究，有望使我们对人类发育障碍的产前起源的理解取得重大进展。尽管它们很重要，但对小鼠胎儿神经行为发育知之甚少。在这项研究中，我们观察了C57 BL/6 J小鼠（一种常见的遗传改变小鼠背景品系）的产前行为模式，并报告了它们与妊娠早期至中期人类胎儿中观察到的行为模式的相似性。在出生前一天（妊娠19天的E18）观察妊娠C57 BL/6 J母鼠的胎仔。胎动的评分和分析包括Prechtl的定性评估方法、肢体间运动同步性（肢体对运动之间的时间关系的测量）和行为状态（通过详细分析高和低幅度肢体运动进行量化）。除胎仔呼吸运动外，在C57 BL/6 J小鼠胎仔中观察到妊娠早期至中期人胎仔通常报告的所有行为类别和模式。我们的研究结果表明，对胎儿C57 BL/6 J小鼠的行为分析可能会对妊娠早期至中期人类行为发育产生重要的新见解。© 2008 Wiley Periodicals，Inc. Dev Psychobiol 51：84-94，2009
The study of fetal neurobehavioral development in genetically altered mice promises a significant advance in our understanding of the prenatal origins of developmental disabilities in humans. Despite their importance, little is known about fetal neurobehavioral development in mice. In this study, we observed prenatal behavioral patterns of the C57BL/6J mouse, a common background strain for genetically altered mice, and report their similarity to those observed in the early to mid‐gestation human fetus. Fetal offspring from pregnant C57BL/6J dams were observed on the day before birth (E18 of a 19‐day gestation). Scoring and analysis of fetal movement included Prechtl's Method for Qualitative Assessment, Interlimb Movement Synchrony, a measure of the temporal relationship between movements of limb pairs, and Behavioral State, quantified through detailed analysis of high and low amplitude limb movements. With the exception of fetal breathing movements, all categories and patterns of behavior typically reported in the early to mid‐gestation human fetus were observed in the C57BL/6J mouse fetus. Our results suggest that behavioral analysis of fetal C57BL/6J mice may yield important new insights into early to mid‐gestation human behavioral development. © 2008 Wiley Periodicals, Inc. Dev Psychobiol 51: 84–94, 2009