Impaired recognition memory in monkeys after damage limited to the hippocampal region
Impaired recognition memory in monkeys after damage limited to the hippocampal region
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DOI：
10.1523/jneurosci.20-01-00451.2000
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发表时间：
2000-01-01
影响因子：
5.3
通讯作者：
Clark, RE
中科院分区：
文献类型：
--
作者：
Zola, SM;Squire, LR;Clark, RE
损伤局限于海马区(海马体、齿状回和下丘)的猴子在两项识别记忆任务中受损：延迟与样本的不匹配任务和视觉配对比较任务。在五组不同的猴子中，识别记忆都受到了损害，无论这些损害是通过缺血程序、射频还是鹅膏糖酸造成的。海马区对于正常的认知记忆表现是必不可少的，这一发现是在当前关于海马体在陈述性记忆中所扮演的角色的想法的背景下考虑的。
Monkeys with lesions limited to the hippocampal region (the hippocampus proper, the dentate gyrus, and the subiculum) were impaired on two tasks of recognition memory: delayed nonmatching to sample and the visual paired-comparison task. Recognition memory was impaired in five different groups of monkeys, whether the lesions were made by an ischemic procedure, by radio frequency, or by ibotenic acid. The finding that the hippocampal region is essential for normal recognition memory performance is considered in the context of current ideas about the role of the hippocampus in declarative memory.