Nocturnal myoclonus: treatment efficacy of clonazepam and temazepam.
Nocturnal myoclonus: treatment efficacy of clonazepam and temazepam.
复制标题
夜间肌阵挛：氯硝西泮和替马西泮的治疗效果。
作者：
Mitler,MM;Browman,CP;Menn,SJ;Gujavarty,K;Timms,RM
在 10 名诊断为失眠伴夜间肌阵挛的患者中研究了氯硝西泮（1 mg h.s.）和替马西泮（30 mg h.s.）。每个受试者在未用药时接受两次夜间多导睡眠图记录，两次在氯硝西泮治疗期间进行，两次在替马西泮治疗期间进行。治疗疗程持续 7 天，并在治疗疗程的第 6 晚和第 7 晚进行记录。治疗期间间隔 14 天的冲洗期。第一次和第二次治疗中使用的药物顺序是随机的。客观和主观睡眠实验室数据表明，两种药物均改善了与夜间肌阵挛相关的失眠患者的睡眠。这两种药物都没有显着减少夜间肌阵挛事件的数量。一般来说，睡眠变化与镇静苯二氮卓类药物产生的变化一致。因此，数据支持临床报告，即氯硝西泮（一种用于治疗癫痫发作的苯二氮卓类药物）可有效改善与夜间肌阵挛相关的睡眠障碍。替马西泮是一种用于治疗失眠的苯二氮卓类药物，被发现是氯硝西泮的合适替代品，可用于治疗与夜间肌阵挛相关的失眠。目前的数据和其他研究表明需要一个模型来解释为什么腿部运动和睡眠障碍可能独立地增加和减少。
Clonazepam (1 mg h.s.) and temazepam (30 mg h.s.) were studied in 10 patients diagnosed as having insomnia with nocturnal myoclonus. Each subject underwent two nocturnal polysomnographic recordings while drug-free, two during treatment with clonazepam, and two during treatment with temazepam. Treatment sessions were 7 days long, and recordings were done on nights 6 and 7 of the treatment sessions. A 14-day washout period separated the treatment sessions. The order of drugs used in the first and second treatment sessions was randomized. Objective and subjective sleep laboratory data showed that both drugs improved the sleep of patients with insomnia in association with nocturnal myoclonus. Neither drug significantly reduced the number of nocturnal myoclonic events. Sleep changes were consistent with those produced by sedative benzodiazepines in general. Thus, the data support clinical reports that clonazepam, a benzodiazepine marketed for the indication of seizure, is useful in improving sleep disturbances associated with nocturnal myoclonus. Temazepam, a benzodiazepine marketed for the indication of insomnia, was found to be a suitable alternative to clonazepam in the treatment of insomnia associated with nocturnal myoclonus. The present data and other studies suggest the need for a model that explains why leg movements and sleep disturbances may wax and wane independently.