A Trial of Transcranial Polarization in Chronic Schizophrenics
A Trial of Transcranial Polarization in Chronic Schizophrenics
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慢性精神分裂症经颅极化试验
DOI：
10.1192/bjp.114.510.635
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发表时间：
1968
影响因子：
10.5
通讯作者：
P. Harper
中科院分区：
文献类型：
--
作者：
K. Lifshitz;P. Harper
大量证据表明，大脑直流电场的改变会导致功能的改变（O’leary and Goldring, 1964）。鉴于此，一组研究人员建立了经颅极化可能有用的临床试验（Lippold和Redfearn, 1964； Redfearn等，1964；Costain等，1964）。在这种方法中，电流在连接在眉毛上方的电极和腿上的电极之间传递。报告的主要变化包括：当头部相对于腿部处于积极状态时，情绪升高，对环境的参与增加；当头部相对于腿部处于消极状态时，情绪下降，安静。目前报道的有效水平一般为250微安左右。在利波德和雷德芬的研究对象中，有7名精神分裂症患者，其中6名患者短暂的dc极化产生了预期的效果。在Redfearn等人的研究对象中，有四名精神分裂症患者，他们都报道了dc头正极化的一些有利效果。这项研究是非控制的。在一项盲控试验中，Costain等人发现头部正极化在一组24例抑郁症患者中具有治疗效果。他们对结果的解释受到了Dawson和Montagu（1965）的挑战。鉴于这些报告，我们决定对经颅极化在改变慢性精神分裂症患者无反应状态方面的可能疗效进行初步研究是有必要的。人们认为，在确定可能的治疗效果方面，一项更纵向的研究将比一项针对大量患者的短期试验更有价值。实验是在罗克兰州立医院的一个研究病房进行的。
Considerable evidence has accumulated that alterations in the direct current fields of the brain can produce alterations in function (O'Leary and Goldring, 1964). In view of this a group of investigators instituted a clinical trial of the possible usefulness of transcranial polarization (Lippold and Redfearn, 1964; Redfearn et al., 1964; Costain et al., 1964). In the approach used a current was passed between electrodes attached just superior to the eyebrows and an electrode on the leg. The principal changes reported consisted of an elevation of mood and an increase in involvement with the environment when the head was positive relatively to the leg and a withdrawal and quietness when the head was negative relatively to the leg. The current level reported as effective was generally of the order of 250 microamperes. Among Lippold and Redfearn's subjects were seven schizophrenics, in six of whom brief D.C. polarization produced the expected effects. Among the subjects of Redfearn et al. were four schizophrenics, in all of whom some favourable effect from D.C. head positive polarization was reported. This study was uncontrolled. In a blind controlled trial, Costain et al. found head-positive polarization to be of therapeutic efficacy in a group of 24 depressed patients. Their interpretation of results was challenged by Dawson and Montagu (1965). In view of these reports, we decided that a pilot study of the possible efficacy of transcranial polarization in altering the non-responsive state of chronic schizophrenic patients was warranted. It was decided that a more longitudinal study would be of greater value in determining possible therapeutic usefulness than a shorter trial on a larger number of patients. The experiment was conducted on one of the research wards of Rockland State Hospital.