Systematic assessment of multi-echo dynamic susceptibility contrast MRI using a digital reference object.
Systematic assessment of multi-echo dynamic susceptibility contrast MRI using a digital reference object.
复制标题
使用数字参考对象对多回波动态磁化率对比 MRI 进行系统评估。
DOI：
10.1002/mrm.27914
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发表时间：
2020
影响因子：
3.3
通讯作者：
Quarles,CChad
中科院分区：
文献类型：
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作者：
Stokes,AshleyM;Semmineh,NatenaelB;Nespodzany,Ashley;Bell,LauraC;Quarles,CChad
脑肿瘤动态磁敏感对比（DSC）MRI受T1和造影剂泄漏效应的不利影响，导致血流动力学指标不准确。虽然多回波采集消除了T1泄漏效应，但对最佳采集参数集没有达成共识。使用计算方法，我们系统地评估了广泛的采集策略，以确定最佳的多回波DSC‐MRI灌注protocol.MethodsUsing a population-based DSC‐MRI digital reference object（DRO），we assessed the impact of preload dosing（无预加载和全剂量预加载），场强（1.5和3 T）、脉冲序列参数（回波时间、重复时间和翻转角）以及相对脑血容量（rCBV）和流量（rCBF）准确度的泄漏校正。我们还比较了多回波DSC‐MRI协议与标准单回波protocols.ResultsMulti‐echo DSC‐MRI是高度一致的所有协议，和多回波rCBV（使用或不使用预加载剂量）有更高的准确性比单回波rCBV。回归分析显示，重复时间和翻转角的选择对多回波rCBV和rCBV的影响最小，表明采集参数具有显著灵活性的潜力。回波时间组合对rCBV的影响最小，但应避免较长的回波时间，特别是在较高场强下。在所有情况下，泄漏校正提高了rCBV准确性。多回波rCBF的偏倚小于单回波rCBF，尽管相对于rCBV，rCBF的准确性总体上降低。结论多回波采集比单回波采集更稳健，基本上将重复时间和翻转角与rCBV准确性解耦。多回波采集不需要预加载剂量，尽管泄漏校正以消除残余泄漏效应对于高rCBV精度仍然是强制性的。
PurposeBrain tumor dynamic susceptibility contrast (DSC) MRI is adversely impacted by T1and contrast agent leakage effects that result in inaccurate hemodynamic metrics. While multi‐echo acquisitions remove T1leakage effects, there is no consensus on the optimal set of acquisition parameters. Using a computational approach, we systematically evaluated a wide range of acquisition strategies to determine the optimal multi‐echo DSC‐MRI perfusion protocol.MethodsUsing a population‐based DSC‐MRI digital reference object (DRO), we assessed the influence of preload dosing (no preload and full dose preload), field strength (1.5 and 3T), pulse sequence parameters (echo time, repetition time, and flip angle), and leakage correction on relative cerebral blood volume (rCBV) and flow (rCBF) accuracy. We also compared multi‐echo DSC‐MRI protocols with standard single‐echo protocols.ResultsMulti‐echo DSC‐MRI is highly consistent across all protocols, and multi‐echo rCBV (with or without use of a preload dose) had higher accuracy than single‐echo rCBV. Regression analysis showed that choice of repetition time and flip angle had minimal impact on multi‐echo rCBV and rCBV, indicating the potential for significant flexibility in acquisition parameters. The echo time combination had minimal impact on rCBV, though longer echo times should be avoided, particularly at higher field strengths. Leakage correction improved rCBV accuracy in all cases. Multi‐echo rCBF was less biased than single‐echo rCBF, although rCBF accuracy was reduced overall relative to rCBV.ConclusionsMulti‐echo acquisitions were more robust than single‐echo, essentially decoupling both repetition time and flip angle from rCBV accuracy. Multi‐echo acquisitions obviate the need for preload dosing, although leakage correction to remove residual leakage effects remains compulsory for high rCBV accuracy.