Thalidomide suppresses melanoma growth by activating natural killer cells in mice.
Thalidomide suppresses melanoma growth by activating natural killer cells in mice.
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DOI：
10.3892/or.16.6.1231
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发表时间：
2006-12
期刊：
影响因子：
4.2
通讯作者：
Ai Kawamata;D. Ito;Takeshi Odani;T. Isobe;M. Iwase;M. Hatori;M. Nagumo
中科院分区：
文献类型：
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作者：
Ai Kawamata;D. Ito;Takeshi Odani;T. Isobe;M. Iwase;M. Hatori;M. Nagumo
虽然沙利度胺（Thd）正在广泛研究其对细胞因子产生和T细胞共刺激的影响，但对其是否能够调节自然杀伤（NK）细胞的活性知之甚少。在这项研究中，Thd对NK细胞活性的影响进行了检查与黑色素瘤的小鼠模型，这主要是拒绝NK细胞依赖性机制。Thd给药显著抑制了皮下B16 F1黑色素瘤的生长（第21天p<0.01）。在Thd处理的小鼠中，观察到显著的脾肿大和脾细胞计数增加。此外，脾NK 1.1+细胞的百分比在Thd处理后10天内升高至约2.5倍。干扰素诱导蛋白（IP）-10、干扰素（IFN）-γ、白细胞介素（IL）-12和IL-18的表达显著上调。细胞毒性分子穿孔素的产生也增加了。这些数据表明，Thd强烈激活小鼠的NK细胞活性，可能导致增强的肿瘤监视防御。
Although thalidomide (Thd) is being extensively investigated for its effects on cytokine production and T cell costimulation, it is poorly understood whether it is capable of modulating the activities of natural killer (NK) cells. In this study, Thd effects on NK cell activity were examined with a murine model of melanoma, which is mostly rejected by NK cell-dependent mechanism. Administration of Thd significantly (p<0.01 on Day 21) suppressed the growth of subcutaneous B16F1 melanoma. In Thd-treated mice, marked splenomegaly and augmented splenocyte count were observed. Additionally, the percentage of splenic NK1.1+ cells was elevated to approximately 2.5-fold within 10 days after Thd treatment. The expression of interferon inducible protein (IP)-10, interferon (IFN)-gamma, interleukin (IL)-12 and IL-18 was remarkably upregulated. Production of the cytotoxic molecule perforin was also augmented. These data suggest that Thd strongly activates NK cell activity in mice, possibly resulting in enhanced tumor surveillance defense.