Nitric oxide synthase blockade and body fluid volumes.
Nitric oxide synthase blockade and body fluid volumes.
复制标题
一氧化氮合酶阻断和体液容量。
DOI：
10.1590/s0100-879x2002000100019
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
C. Arranz
中科院分区：
文献类型：
--
作者：
A. Balaszczuk;A. Tomat;S. Bellucci;A. Fellet;C. Arranz
The influence of chronic nitric oxide synthase inhibition with N G-nitro-L-arginine methyl ester (L-NAME) on body fluid distribution was studied in male Wistar rats weighing 260-340 g. Extracellular, interstitial and intracellular spaces, as well as plasma volume were measured after a three-week treatment with L-NAME (approximately 70 mg/kg per 24 h in drinking water). An increase in extracellular space (16.1 +/- 1.1 vs 13.7 +/- 0.6 ml/100 g in control group, N = 12, P<0.01), interstitial space (14.0 +/- 0.9 vs 9.7 +/- 0.6 ml/100 g in control group, P<0.001) and total water (68.7 +/- 3.9 vs 59.0 +/- 2.9 ml/100 g, P<0.001) was observed in the L-NAME group (N = 8). Plasma volume was lower in L-NAME-treated rats (2.8 +/- 0.2 ml/100 g) than in the control group (3.6 +/- 0.1 ml/100 g, P<0.001). Blood volume was also lower in L-NAME-treated rats (5.2 +/- 0.3 ml/100 g) than in the control group (7.2 +/- 0.3 ml/100 g, P<0.001). The increase in total ratio of kidney wet weight to body weight in the L-NAME group (903 +/- 31 vs 773 +/- 45 mg/100 g in control group, P<0.01) but not in total kidney water suggests that this experimental hypertension occurs with an increase in renal mass. The fact that the heart weight to body weight ratio and the total heart water remained constant indicates that, despite the presence of high blood pressure, no modification in cardiac mass occurred. These data show that L-NAME-induced hypertension causes alterations in body fluid distribution and in renal mass.
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影响因子：
19.6
作者：
S. Xiao;L. Wagner;R. Schmidt;C. Baylis
通讯作者：
S. Xiao;L. Wagner;R. Schmidt;C. Baylis
慢性一氧化氮抑制性高血压的演变：与肾功能的关系。
DOI：
10.1161/01.hyp.31.1.21
发表时间：
1998
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Qiu,C;Muchant,D;Beierwaltes,WH;Racusen,L;Baylis,C
通讯作者：
Baylis,C
麻醉犬急性和进行性一氧化氮合成抑制的血流动力学和肾脏影响。
DOI：
10.1152/ajpregu.2001.280.1.r143
发表时间：
2001
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
Cases,A;Haas,J;Burnett,JC;Romero,JC
通讯作者：
Romero,JC
影响因子：
37.8
作者：
Bartunek, J;Weinberg, EO;Lorell, BH
通讯作者：
Lorell, BH