Patterns of Occurrence and Outcomes of Contralateral Breast Cancer: Analysis of SEER Data.
Patterns of Occurrence and Outcomes of Contralateral Breast Cancer: Analysis of SEER Data.
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DOI：
10.3390/jcm7060133
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发表时间：
2018-05-31
影响因子：
3.9
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Xiong Z;Yang L;Deng G;Huang X;Li X;Xie X;Wang J;Shuang Z;Wang X
目前缺乏对乳腺癌（BC）患者对侧乳腺癌（CBC）风险的时间趋势的基于人群的估计。从监测、流行病学和最终结果数据库中收集诊断为CBC的BC患者的数据。使用Kaplan-Meier方法计算CBC发生率，并使用联合点回归评估CBC发生率的时间趋势。采用倾向评分（PS）和多变量考克斯回归与竞争风险模型计算生存分析。我们发现，212,630例早期乳腺癌患者中有10,944例随后被诊断为对侧乳腺继发性乳腺癌。5年、10年、15年和20年累积CBC发生率分别为1.9%、4.6%、7.6%和10.5%。年轻（<40岁）、黑人、激素受体阴性和接受过放疗与CBC发生的高风险相关。CBC发病率在初次癌症诊断后的前11年持续上升，从11岁到21岁上升趋势放缓，从21岁到24岁呈下降趋势。CBC诊断与生存率显著负相关。我们报告了基于人群的CBC发生模式和危险因素的估计。在最初的BC诊断后的前21年内，患者患CBC的风险很高。
Population-based estimates are lacking for the temporal trends in the contralateral breast cancer (CBC) risk for patients with breast cancer (BC). Data for BC patients diagnosed with CBC were collected from the Surveillance, Epidemiology, and End Results database. CBC incidence was calculated using the Kaplan-Meier method and the temporal trend in CBC incidence was assessed using joinpoint regression. Survival analysis was calculated using propensity scoring (PS) and multivariate Cox regression with a competing risk model. We found that 10,944 of 212,630 patients with early-stage BC were subsequently diagnosed with secondary BC in the contralateral breast. The 5-, 10-, 15-, and 20-year cumulative CBC incidences were 1.9, 4.6, 7.6, and 10.5%, respectively. Being younger (<40 years), black, hormone receptor-negative, and having undergone radiotherapy were correlated with a high risk of CBC occurrence. CBC incidence increased continuously in the first 11 years after the initial cancer diagnosis, and the upward trend slowed from years 11 to 21, and tended to decline from years 21 to 24. CBC diagnosis was significantly and negatively associated with survival. We reported population-based estimates of the CBC occurrence pattern and risk factors. Patients are at high risk of developing CBC in the first 21 years after the initial BC diagnosis.
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影响因子：
28.4
作者：
Rosenberg, Shoshana M.;Ruddy, Kathryn J.;Tamimi, Rulla M.;Gelber, Shari;Schapira, Lidia;Come, Steven;Borges, Virginia F.;Larsen, Bryce;Garber, Judy E.;Partridge, Ann H.
通讯作者：
Partridge, Ann H.
DOI：
10.1016/s0140-6736(15)01129-0
发表时间：
2016-02-27
期刊：
Lancet (London, England)
影响因子：
--
作者：
Forbes JF;Sestak I;Howell A;Bonanni B;Bundred N;Levy C;von Minckwitz G;Eiermann W;Neven P;Stierer M;Holcombe C;Coleman RE;Jones L;Ellis I;Cuzick J;IBIS-II investigators
通讯作者：
IBIS-II investigators
影响因子：
120.7
作者：
Kuchenbaecker, Karoline B.;Hopper, John L.;Antoniou, Antonis C.
通讯作者：
Antoniou, Antonis C.
影响因子：
168.9
作者：
Narod, SA;Brunet, JS;Lynch, H
通讯作者：
Lynch, H
影响因子：
3.8
作者：
Gronwald, Jacek;Robidoux, Andre;Kim-Sing, Charmaine;Tung, Nadine;Lynch, Henry T.;Foulkes, William D.;Manoukian, Siranoush;Ainsworth, Peter;Neuhausen, Susan L.;Demsky, Rochelle;Eisen, Andrea;Singer, Christian F.;Saal, Howard;Senter, Leigha;Eng, Charis;Weitzel, Jeffrey;Moller, Pal;Gilchrist, Dawna M.;Olopade, Olufunmilayo;Ginsburg, Ophira;Sun, Ping;Huzarski, Tomasz;Lubinski, Jan;Narod, Steven A.
通讯作者：
Narod, Steven A.