FORMULATION STRATEGY, STABILITY ISSUES, SAFETY AND EFFICACY EVALUATIONS OF ACACIA CATECHU WHITENING CREAM
FORMULATION STRATEGY, STABILITY ISSUES, SAFETY AND EFFICACY EVALUATIONS OF ACACIA CATECHU WHITENING CREAM
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金合欢儿茶美白霜的配方策略、稳定性问题、安全性和功效评价
DOI：
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发表时间：
2019
影响因子：
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通讯作者：
R. Boonruang
中科院分区：
文献类型：
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作者：
O. Anurukvorakun;Narongrit Lahpun;R. Boonruang
目的：探讨含有金合欢心材提取物的新型美白霜的配方策略、稳定性问题、安全性和功效（酪氨酸酶抑制活性和防晒性）。
方法：以左旋多巴为底物，研究儿茶提取物的酪氨酸酶抑制活性。硅胶和三片防光滤镜的组合；天然紫外线过滤剂（儿茶提取物）、化学和物理过滤剂的配方和评估。对所开发的美白霜的防晒系数（SPF）、稳定性、皮肤过敏或刺激以及满意度进行了调查。
结果：儿茶提取物表现出很强的酪氨酸酶抑制活性，在120 mg/ml浓度下抑制率为61.58%，而曲酸阳性对照在120 mg/ml浓度下抑制率为98.73%。令人印象深刻的是，带有物理和化学紫外线过滤剂的儿茶美白霜的最高 SPF 为 30。而没有这些过滤剂的儿茶美白霜的最高 SPF 为 24。开发的美白霜在冰箱中储存时没有观察到颜色、液化和相分离的变化。二十名志愿者中，十八名志愿者没有皮肤刺激，其中一名志愿者出现发红（短暂性），另一名志愿者对开发的美白霜出现红斑或非常轻微的刺激。此外，儿茶美白霜与市售美白霜的满意度差异无统计学意义（p>0.05）。
结论：显然，儿茶美白霜具有非常高的功效、稳定性和安全性，适合在不久的将来成为商业产品。
Objective: To investigate among formulation strategy, stability issues, safety and efficacy (tyrosinase inhibitory activity and sun protection) of a novel whitening cream containing Acacia catechu heartwood extract.
Methods: The tyrosinase inhibitory activity of the A. catechu extract was investigated using L-DOPA as a substrate. A combination of silicone and three photo-protective filters; natural UV filter (A. catechu extract), chemical and physical filters, was formulated and evaluated. The Sun Protection Factor (SPF), stability, skin allergy or irritation, and the satisfaction of the developed whitening creams, were investigated.
Results: The A. catechu extract showed the strong tyrosinase inhibitory activity with the percentage of inhibition of 61.58% at the concentration of 120 mg/ml compared to a positive control of kojic acid (98.73 % inhibition) at the same concentration of 120 mg/ml. impressively, the highest SPF of A. catechu whitening cream with physical and chemical UV filters was 30. While, the highest SPF of the A. catechu whitening cream without those filters, was 24. No changes in color, liquefaction and phase separation were observed for the developed whitening cream when stored in the refrigerator. Among the twenty volunteers, eighteen volunteers had no skin irritation, while one of them had redness (Transient) and then another one had erythema or very slight irritation to the developed whitening creams. Besides, there was no statistically significant difference for the satisfaction between A. catechu whitening creams and commercial whitening creams (p>0.05).
Conclusion: Obviously, A. catechu whitening creams had very high efficacy, stability, and safety for being a commercial product in a near future.
影响因子：
2.4
作者：
Morgan SL;Baggott JE;Moreland L;Desmond R;Kendrach AC
通讯作者：
Kendrach AC