OLFACTORY-BULB CHANGES IN ALZHEIMERS-DISEASE
OLFACTORY-BULB CHANGES IN ALZHEIMERS-DISEASE
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DOI：
10.1007/bf00688261
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发表时间：
1987-01-01
影响因子：
12.7
通讯作者：
BRAAK, H
中科院分区：
文献类型：
--
作者：
OHM, TG;BRAAK, H
用病理纤维的银染色和细胞体的尼氏染色相结合的方法对阿尔茨海默病病例和年龄匹配对照的嗅球进行了检查。前嗅核内可见神经性斑块。前嗅核和嗅球除外层纤维层外的所有层均可见神经原纤维缠结和神经原丝。嗅球的缠结神经元被鉴定为簇状细胞、外颗粒细胞和形成前嗅核吻侧的两种不同类型的神经细胞。
Olfactory bulbs in cases of Alzheimer''s disease and age-matched controls have been examined by means of combining silver staining of pathological filaments with pigment-Nissl staining of the cell bodies. Neuritic plaques were found in the anterior olfactory nucleus. Neurofibrillary tangles and neuropil threads occurred in the anterior olfactory nucleus and in all layers of the olfactory bulb except the outer fibrous layer. The tangle-bearing neurons of the olfactory bulb were identified as tufted cells, outer granule cells, and two different types of nerve cells forming the rostral part of the anterior olfactory nucleus.