Preparation of ceramic microspheres for in situ radiotherapy of deep-seated cancer
Preparation of ceramic microspheres for in situ radiotherapy of deep-seated cancer
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DOI：
10.1016/s0142-9612(03)00094-2
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发表时间：
2003-08-01
期刊：
影响因子：
14
通讯作者：
Sawada, Y
中科院分区：
文献类型：
--
作者：
Kawashita, M;Shineha, R;Sawada, Y
放射治疗是治疗癌症最有效的方法之一。然而，外部照射只能为深部癌症提供小剂量，并且常常对健康组织造成损害。据报道，直径20-30μm的17Y(2)O(3)-19Al(2)O(3)-64SiO(2)(mol%)玻璃微球可用于癌症的原位照射。这种玻璃中的钇 89 (Y-89) 可被中子轰击形成 β 发射体 Y-90（半衰期 = 64.1 小时）。当注射到癌症附近时，这种活化的玻璃微球可以提供大的局部剂量的β辐射。微球中玻璃的Y2O3含量仅限于17mol%。需要开发具有更高 Y2O3 含量的化学耐用微球。自然丰度为 100% 的磷 31 (P-31) 也可以通过中子轰击激活，形成 β 发射体 (32)p（半衰期 = 14.3 d）。含有高磷含量的化学耐用微球预计对癌症治疗更有效。我们使用高频感应热等离子体熔化技术制备了纯 Y2O3 和 YPO4 微球，并研究了所得结构和化学耐久性。我们成功制备了光滑、高度球形的多晶Y2O3和YPO4微球，直径在20-30μm范围内。 Y2O3 和 YPO4 微球在 pH = 6 和 7 缓冲的盐水溶液中均表现出高化学耐久性。这些微球预计在癌症原位放射治疗中比传统玻璃微球更有效。 (C) 2003 Elsevier Science Ltd. 保留所有权利。
Radiotherapy is one of the most effective treatments for cancers. However, external irradiation provides only small doses to deep-seated cancers, and often causes damage to healthy tissues. It has been reported that 20-30 mum diameter 17Y(2)O(3)-19Al(2)O(3)-64SiO(2) (mol%) glass microspheres are useful for the in situ irradiation of cancers. Yttrium-89 (Y-89) in this glass can be neutron bombarded to form the beta-emitter Y-90 (half-life = 64.1 h). When injected in the vicinity of the cancer, such activated glass microspheres can provide a large localized dose of beta-radiation. The Y2O3 content of the glass in the microspheres is limited to only 17mol%. Chemically durable microspheres with a higher Y2O3 content need to be developed. Phosphorus-31 (P-31) with 100% natural abundance can also be activated by neutron bombardment to form the beta-emitter (32)p, (half-life = 14.3 d). Chemically durable microspheres containing a high phosphorus content are expected to be more effective for cancer treatment. We prepared pure Y2O3 and YPO4 microspheres using a high-frequency induction thermal plasma melting technique, and investigated the resulting structure and chemical durability. We successfully prepared smooth, highly spherical polycrystalline Y2O3 and YPO4 microspheres with diameters in the range 20-30 mum. Both the Y2O3 and YPO4 microspheres showed high chemical durability in saline solutions buffered at pH = 6 and 7. These microspheres are expected to be more effective than the conventional glass microspheres for the in situ radiotherapy of cancer. (C) 2003 Elsevier Science Ltd. All rights reserved.