A rapid capsaicin-activated current in rat trigeminal ganglion neurons.
A rapid capsaicin-activated current in rat trigeminal ganglion neurons.
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大鼠三叉神经节神经元中的快速辣椒素激活电流。
DOI：
10.1073/pnas.91.2.738
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发表时间：
1994
影响因子：
11.1
通讯作者：
Simon,SA
中科院分区：
文献类型：
--
作者：
Liu,L;Simon,SA
疼痛纤维的一个亚群被辣椒素激活，辣椒素是红辣椒中的成分，当食用或放在皮肤上时会产生灼烧感。先前对背根神经节神经元的研究表明，辣椒素通过单个缓慢激活和失活的内向电流激活感觉神经。在大鼠三叉神经元中，我们发现了第二种辣椒素激活的内向电流。该电流与慢电流的区别在于，它快速激活和失活，需要 Ca2+ 才能激活，并且对强效辣椒素激动剂树脂毒素不敏感。与较慢的电流一样，快速电流也会被钌红和辣椒西平抑制。这两种辣椒素激活的内向电流与通过将pH降低至6.0激活的两种内向电流有许多相似之处。这些相似之处包括动力学、逆转电位、对 Ca2+ 的反应以及钌红和辣椒西平的抑制作用。这些结果表明，酸性刺激可能是辣椒素门控电流的内源性激活剂，因此可以合理解释为什么当血浆酸度增加时会产生疼痛，如在缺血和炎症期间发生的情况。
A subpopulation of pain fibers are activated by capsaicin, the ingredient in red peppers that produces a burning sensation when eaten or placed on skin. Previous studies on dorsal root ganglion neurons indicated that capsaicin activates sensory nerves via a single slowly activating and inactivating inward current. In rat trigeminal neurons, we identified a second capsaicin-activated inward current. This current can be distinguished from the slow one in that it rapidly activates and inactivates, requires Ca2+ for activation, and is insensitive to the potent capsaicin agonist resiniferatoxin. The rapid current, like the slower one, is inhibited by ruthenium red and capsazepine. The two capsaicin-activated inward currents share many similarities with the two inward currents activated by lowering the pH to 6.0. These similarities include kinetics, reversal potentials, responses to Ca2+, and inhibition by ruthenium red and capsazepine. These results suggest that acidic stimuli may be an endogenous activator of capsaicin-gated currents and therefore may rationalize why pain is produced when the plasma acidity is increased, as occurs during ischemia and inflammation.