Age‐related differences in prefrontal, parietal, and hippocampal activations during correct rejections of faces
Age‐related differences in prefrontal, parietal, and hippocampal activations during correct rejections of faces
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DOI：
10.1111/jpr.12017
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发表时间：
2014
影响因子：
0.8
通讯作者：
T. Tsukiura;Y. Shigemune;R. Nouchi;T. Kambara;R. Kawashima
中科院分区：
文献类型：
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作者：
T. Tsukiura;Y. Shigemune;R. Nouchi;T. Kambara;R. Kawashima
老年人比年轻人更有可能在记忆从未发生过的事件方面表现出与年龄相关的增长。然而，很少有人知道的神经机制，潜在的增加发生的错误警报在老年人。为了研究这个问题，本fMRI研究探讨了年龄相关的差异，正确的拒绝激活过程中检索的面孔记忆。在行为数据中，老年人在主观回忆反应中表现出比年轻人更高的误报率。根据功能磁共振成像数据，在正确拒绝过程中，在额下回、缘上回和海马中发现了与年龄相关的脑激活减少。此外，在正确的拒绝过程中，下额叶和边缘上区域的激活之间的相互作用在老年人中显着低于年轻人。这些研究结果表明，与年龄相关的腹侧前额叶区域，这是参与在检索过程中的源监测过程中，和下顶叶区域，这是与合作与海马回忆之间的相互作用下降，可能会导致受损的分化在老年人的旧的和新的刺激。
Older adults are more likely than young adults to show age-related increases in remembering events that never occurred. However, little is known about the neural mechanisms underlying the increased occurrence of false alarms in older adults. To investigate this issue, this fMRI study examined age-related differences in correct rejection activations during the retrieval of memory for faces. In behavioral data, older adults showed a higher rate of false alarms than young adults in subjective recollection responses. From fMRI data, an age-related decrease in brain activations during correct rejections was identified in the inferior frontal gyrus, supramarginal gyrus, and hippocampus. In addition, interaction between activations in the inferior frontal and supramarginal regions during correct rejections was significantly lower in older adults than in young adults. These findings suggest that an age-related decline in interaction between the ventral prefrontal region, which is involved in the source monitoring process during retrieval, and the inferior parietal region, which is associated with recollection by cooperating with the hippocampus, could induce impaired differentiation between old and novel stimuli in older adults.