Helical Nanomachines as Mobile Viscometers
Helical Nanomachines as Mobile Viscometers
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DOI：
10.1002/adfm.201705687
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发表时间：
2018-06-20
影响因子：
19
通讯作者：
Ghosh, Ambarish
中科院分区：
文献类型：
--
作者：
Ghosh, Arijit;Dasgupta, Debayan;Ghosh, Ambarish
各种各样的应用被设想和展示与人工微和纳米机器，从靶向药物或基因递送，显微外科手术，环境传感，等等。在这里，它演示了如何螺旋纳米机器可以用来测量和映射一个复杂的异质环境的局部机械性能。纳米机器的位置是使用外部施加的磁场精确控制的，而它们的瞬时方向提供了对周围介质粘度的高空间和时间精度的估计。该测量技术可应用于牛顿和剪切变稀介质，所有的实验结果与理论分析吻合得很好。据信，螺旋纳米机器的这种新应用与生物物理研究和微流体技术特别相关。
A wide variety of applications are envisioned and demonstrated with artificial micro- and nanomachines, ranging from targeted drug or gene delivery, microsurgery, environmental sensing, and many more. Here, it is demonstrated how helical nanomachines can be used to measure and map the local mechanical properties of a complex heterogeneous environment. The positions of the nanomachines are precisely controlled using externally applied magnetic fields, while their instantaneous orientations provide estimation of the viscosity of the surrounding medium with high spatial and temporal accuracy. The measurement technique can be applied to both Newtonian as well as shear thinning media, and all experimental results are in good agreement with the theoretical analysis. It is believed that this novel application of helical nanomachines can be particularly relevant to biophysical studies and microfluidic technologies.