Optimization of stripline-based microfluidic chips for high-resolution NMR
Optimization of stripline-based microfluidic chips for high-resolution NMR
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DOI：
10.1016/j.jmr.2009.09.007
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发表时间：
2009-12-01
影响因子：
2.2
通讯作者：
Gardeniers, J. G. E.
中科院分区：
文献类型：
--
作者：
Bart, J.;Janssen, J. W. G.;Gardeniers, J. G. E.
在这里，我们报告的优化，制造和实验表征的带状线为基础的微流体NMR探针，实现在硅基板上。带状线的几何形状的射频均匀性，灵敏度和光谱分辨率方面建模。使用这些模型，最佳的尺寸比，发现，持有每一个样本量。在此基础上，实现了一种简单的集成化带状线微流控芯片。详细介绍了该芯片的制作过程。我们实现了0.47 nmol/根Hz的灵敏度和0.7 Hz的分辨率。rf-homlop（A（810度）/A（90度）。）为76%，适用于葡萄糖的2D-NMR分析。(C)2009 Elsevier Inc. All rights reserved.
We here report on the optimization, fabrication and experimental characterization of a stripline-based microfluidic NMR probe, realized in a silicon substrate. The stripline geometry was modelled in respect of rf-homogeneity, sensitivity and spectral resolution. Using these models, optimal dimensional ratios were found, which hold for every sample size. Based on the optimized parameters, a simple integrated stripline-based microfluidic chip was realized. The fabrication of this chip is described in detail. We achieved a sensitivity of 0.47 nmol/root Hz and a resolution of 0.7 Hz. The rf-homlogeneity (A(810 degrees)/A(90 degrees).) was 76% and was proved to be suitable for 2D-NMR analysis of glucose. (C) 2009 Elsevier Inc. All rights reserved.