Neurotransmitter imbalance in serum of psoriatic patients in exacerbation stage with comorbid psychoemotional disorders
Neurotransmitter imbalance in serum of psoriatic patients in exacerbation stage with comorbid psychoemotional disorders
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DOI：
10.1111/dth.13337
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发表时间：
2020-04-15
影响因子：
3.6
通讯作者：
Jafferany, Mohammad
中科院分区：
文献类型：
--
作者：
Matiushenko, Valeriia;Kutasevych, Yanina;Jafferany, Mohammad
心理因素在银屑病的表现和加重中的作用是众所周知的。急性和慢性压力、焦虑和抑郁会影响先天和后天免疫反应。银屑病皮损的恶化伴随着炎症介质的产生增加，这可能导致神经递质的失衡和抑郁和焦虑症状的发展。对银屑病急性加重期患者血清中抑制性神经递质的作用进行了评估。本文对40例银屑病急性发作期患者进行了检查。采用斯皮尔伯格状态-特质焦虑量表(STAI)和贝克抑郁量表(BDI)评定焦虑和抑郁参数。同时测定血清中5-羟色胺和γ-氨基丁酸(GABA)浓度。银屑病患者存在明显的焦虑和抑郁障碍。银屑病患者急性期5-羟色胺水平失衡，血清GABA水平下降。只有焦虑症患者的5-羟色胺水平升高。我们的研究结果表明，银屑病患者急性期神经递质的失衡对预测情绪幸福感的发展具有重要意义。
The role of psychological factors in the manifestation and exacerbation of psoriasis is well known. Acute and chronic stress, anxiety, and depression affect the reactions of innate and acquired immunity. The exacerbations of psoriatic lesions are accompanied by increased production of inflammatory mediators, which could contribute to the imbalance of neurotransmitters and the development of symptoms of depression and anxiety. The role of inhibitory neurotransmitters in the serum of patients with psoriasis exacerbation with comorbid emotional disorders is assessed. Forty patients with psoriasis in the exacerbation stage were examined. Spielberger State-Trait Anxiety Inventory (STAI) and the Beck Depression Inventory (BDI) scale were used to assess anxiety and depression parameters. We also evaluated the concentration of serotonin and gamma-aminobutyric acid (GABA) in the serum. Patients with psoriasis had significant anxiety and depressive disorders. An imbalance in serotonin levels and a decrease in serum GABA levels in patients with psoriasis in the acute stage were noted. Only patients with anxiety disorder had increased serotonin levels. Our findings suggest that the imbalance of neurotransmitters in patients with psoriasis in the acute stage is important in predicting the development of the emotional well-being.