Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks
Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks
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DOI：
10.1126/science.1211095
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发表时间：
2011-12-16
期刊：
影响因子：
56.9
通讯作者：
Gerstner, W.
中科院分区：
文献类型：
--
作者：
Vogels, T. P.;Sprekeler, H.;Gerstner, W.
皮质神经元接受平衡的兴奋性和抑制性突触电流。这种平衡可以通过抑制性突触的突触可塑性以经验依赖的方式建立和维持。我们表明，这一机制为自然刺激反应中观察到的稀疏放电模式提供了解释，并与最近观察到的兴奋性和抑制性感受场可塑性的相互作用很好地吻合。在合适的递归网络中引入抑制可塑性提供了一种导致异步不规则网络状态的动态平衡机制。此外，它可以容纳具有活动模式的突触记忆，这些模式从背景状态变得不可区分，但可以被外部刺激重新激活。我们的结果表明，抑制可塑性在功能性皮质回路的形成和维持中起着重要作用。
Cortical neurons receive balanced excitatory and inhibitory synaptic currents. Such a balance could be established and maintained in an experience-dependent manner by synaptic plasticity at inhibitory synapses. We show that this mechanism provides an explanation for the sparse firing patterns observed in response to natural stimuli and fits well with a recently observed interaction of excitatory and inhibitory receptive field plasticity. The introduction of inhibitory plasticity in suitable recurrent networks provides a homeostatic mechanism that leads to asynchronous irregular network states. Further, it can accommodate synaptic memories with activity patterns that become indiscernible from the background state but can be reactivated by external stimuli. Our results suggest an essential role of inhibitory plasticity in the formation and maintenance of functional cortical circuitry.