A hospital-based prospective study of perinatal infection with human immunodeficiency virus type 1.
A hospital-based prospective study of perinatal infection with human immunodeficiency virus type 1.
复制标题
一项以医院为基础的人类免疫缺陷病毒 1 型围产期感染的前瞻性研究。
DOI：
10.1016/s0022-3476(05)82145-6
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Scott,GB
中科院分区：
文献类型：
--
作者：
Hutto,C;Parks,WP;Lai,SH;Mastrucci,MT;Mitchell,C;Munoz,J;Trapido,E;Master,IM;Scott,GB
大多数患有儿童获得性免疫缺陷综合征和感染人类免疫缺陷病毒1型(HIV-1)的婴儿是由其母亲在围产期感染的。为了确定暴露的婴儿感染的比例，我们在佛罗里达州迈阿密的一家大都市医院分娩的HIV-1感染妇女中进行了一项以医院为基础的前瞻性研究。一组未感染的妇女和她们的婴儿也被纳入，并纵向跟踪2年，以评估实验室和临床测量。现在，82名感染艾滋病毒-1的母亲所生婴儿的中位随访期为18个月。本组婴儿感染比例为0.30(25/82)。110名HIV-1血清阴性母亲所生的婴儿中，没有一人血清阳性。通过病毒分离，感染婴儿和未感染婴儿很容易区分。没有单一的免疫学或血液学指标预测所有6个月或以下的艾滋病毒感染风险婴儿的感染。然而，作为一个整体，感染婴儿在6个月大时可以通过许多免疫学指标区分感染婴儿和未感染指数婴儿；CD4+淋巴细胞绝对数和CD4+/CD8+淋巴细胞比率是最能预测感染的变量。在回顾研究中，80%的受感染婴儿在出生后24个月内出现临床疾病。这项研究从一家医院提供了HIV-1围产期传播风险和幼儿感染的早期相关性的文件。
Most infants with pediatric acquired immunodeficiency syndrome and infections with human immunodeficiency virus type 1 (HIV-1) are infected perinatally by their mothers. To determine the proportion of exposed infants who are infected, we conducted a hospital-based prospective study in HIV-1-infected women whose infants were delivered at a single metropolitan hospital in Miami, Fla. A population of uninfected women and their infants was also enrolled and followed longitudinally for 2 years to assess laboratory and clinical measurements. The median follow-up is now 18 months for 82 infants born to HIV-1-infected mothers. The proportion of infected infants in this group is 0.30 (25/82). None of the infants born to 110 HIV-1-seronegative mothers were seropositive. Infected infants were easily distinguished from noninfected infants by virus isolation. No single immunologic or hematologic measure was predictive of infection for all infants at risk for HIV-1 infection who were 6 months of age or younger. As a group, however, infected infants could be distinguished from uninfected index infants by a number of immunologic measures by 6 months of age; the absolute number of CD4+lymphocytes and the CD4+/CD8+lymphocyte ratio were the variables most predictive of infection. As in retrospective studies, clinical disease developed in 80% of infected infants within the first 24 months of life. This study provides documentation of HIV-1 perinatal transmission risk and early correlates of infection in young infants from a single hospital.