Fatty acid binding sites of serum albumin as membrane receptor analogs for streptococcal lipoteichoic acid
Fatty acid binding sites of serum albumin as membrane receptor analogs for streptococcal lipoteichoic acid
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血清白蛋白的脂肪酸结合位点作为链球菌脂磷壁酸的膜受体类似物
DOI：
10.1128/iai.29.1.119-122.1980
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发表时间：
1980
影响因子：
3.1
通讯作者：
E. Beachey
中科院分区：
文献类型：
--
作者：
W. A. Simpson;I. Ofek;E. Beachey
研究了牛血清白蛋白抑制A组链球菌脂磷壁酸（LTA）与人细胞结合的能力。在存在抗LTA的情况下，白蛋白以剂量依赖性方式阻断LTA使红细胞致敏凝集的能力。用放射性标记的LTA直接证明了LTA与红细胞结合的抑制作用。在白蛋白/LTA摩尔比为1.5：1时，放射性标记的LTA与红细胞的白蛋白结合被抑制45%。在存在白蛋白的情况下，放射性标记的LTA与红细胞的结合分析表明，白蛋白竞争性抑制LTA与推定的细胞膜受体的结合，表明白蛋白和红细胞均与LTA分子上的相同部分结合。
The ability of bovine serum albumin to inhibit the binding of group A streptococcal lipoteichoic acid (LTA) to human cells was investigated. Albumin blocked the ability of LTA to sensitize erythrocytes to agglutinate in the presence of anti-LTA in a dose-dependent manner. The inhibition of LTA binding to erythrocytes was demonstrated directly with radiolabeled LTA. At an albumin/LTA molar ratio of 1.5:1, albumin binding of the radiolabeled LTA at erythrocytes was inhibited by 45%. Analysis of the binding of radiolabeled LTA to erythrocytes in the presence of albumin indicated that albumin competitively inhibited the binding of LTA to putative cell membrane receptors, indicating that albumin and erythrocytes both bind to the same moiety on the LTA molecule.