Fluorescent Arylethynyl Hamilton Receptors for Barbiturate Sensing
Fluorescent Arylethynyl Hamilton Receptors for Barbiturate Sensing
复制标题
用于巴比妥传感的荧光芳基乙炔基汉密尔顿受体
DOI：
10.1021/acs.joc.9b00978
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Pluth, Michael D.
中科院分区：
文献类型：
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作者：
Seidenkranz, Daniel T.;Pluth, Michael D.
由于互补氢键供体/受体相互作用，巴比妥酸盐是预组织受体中分子识别的常见靶标。虽然许多这样的受体表现出对巴比妥类客体的高选择性和亲和力，但这些系统中相对较少具有用于感测应用的期望的物理化学性质。在这里，我们报告的合成，光电性能，和一套荧光芳基乙炔基汉密尔顿受体的结合亲和力。我们还深入了解了这些系统的高效荧光设计所需的设计原则，以用作荧光巴比妥酸盐传感器。
Barbiturates are common targets for molecular recognition in preorganized receptors due to complementary hydrogen-bond donor/acceptor interactions. Although many such receptors exhibit high selectivity and affinity for barbiturate guests, relatively few of these systems have desirable photophysical properties for sensing applications. Here, we report the synthesis, optoelectronic properties, and binding affinities of a suite of fluorescent arylethynyl Hamilton receptors. We also provide insights into the design principles required for efficient fluorogenic design of these systems to function as fluorescent barbiturate sensors.