Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction
Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction
复制标题
DOI：
10.1196/annals.1402.004
复制
发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Lee, Francis Young-In
中科院分区：
文献类型：
--
作者：
Aydemir, Ayse B. Celil;Lee, Stephenie;Lee, Francis Young-In
Bone adapts to its environment. Osteoblasts and osteocytes are subject to mechanical load in vivo. It has been shown that osteoblasts alter cytokine expression in response to mechanical loading. However, signal transduction pathways that mediate bone cell response to mechanical stimuli have not been elucidated. In this study, we report an increase in proinflammatory gene expression in response to fluid shear stress (FSS) in human mesenchymal stem cells (hMSCs) and mouse preosteoblasts. Fluid shear stress (FSS)-induced effect was blocked by the inhibition of the calcineurin-NFATc1 axis, thus implicating a role for nuclear factor of activated T cells (NFAT) signaling in mechanotransduction.
