Liver fibrosis in asymptomatic polyvinyl chloride workers
Liver fibrosis in asymptomatic polyvinyl chloride workers
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DOI：
10.1097/01.jom.0000137722.66767.38
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发表时间：
2004-09-01
影响因子：
3.2
通讯作者：
Cheng, TJ
中科院分区：
文献类型：
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作者：
Hsiao, TJ;Wang, JD;Cheng, TJ
本研究旨在确定氯乙烯单体（VCM）暴露是否与肝纤维化相关。对347名职业接触氯乙烯工人进行了肝脏超声检查和肝功能常规检查。氯乙烯单体累积剂量（ppm-月）是通过将空气中氯乙烯单体浓度水平与就业月份的乘积相加来估算的。肝纤维化定义为使用超声诊断的肝硬化前期和肝硬化受试者。与没有高暴露工作史的工人相比，有高暴露工作史的工人发生肝纤维化的风险显着增加（比值比5.5，95%置信区间1.7-25.4）。我们的结论是，有一个增加的风险，发展肝纤维化的PVC工人谁有高暴露于氯乙烯。
This study was designed to determine whether vinyl chloride monomer (VCM) exposure is associated with liver fibrosis. A total of 347 workers with occupational exposure to VCM were systemically examined using liver ultrasonography and routine liver function tests. Vinyl chloride monomer cumulative dose (ppm-month) was estimated by summing the products of air VCM concentration levels and months of employment. Liver fibrosis was defined in subjects with precirrhosis and cirrhosis of liver diagnosed using ultrasonography. Significantly increased risks of developing liver fibrosis were found in workers who had history of high exposure jobs (odds ratio 5.5, 95% confidence interval 1.7-25.4) when compared with workers who did not have history of high exposure Jobs. We concluded that there was an increased risk of developing liver fibrosis in PVC workers who had high exposure to VCM.