Formation of Microparticles in the Injured Brain of Patients with Severe Isolated Traumatic Brain Injury
Formation of Microparticles in the Injured Brain of Patients with Severe Isolated Traumatic Brain Injury
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DOI：
10.1089/neu.2013.3168
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发表时间：
2014-12-01
影响因子：
4.2
通讯作者：
Wallen, Hakan
中科院分区：
文献类型：
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作者：
Nekludov, Michael;Mobarrez, Fariborz;Wallen, Hakan
循环微粒 (MP) 的潜在病理生理学作用已在心血管和血栓性疾病等多种疾病中得到认识。创伤性脑损伤（TBI）具有复杂的病理生理学，涉及凝血障碍和炎症。我们研究了 16 名严重孤立性 TBI 患者的内皮、血小板和白细胞来源的微粒（分别为 EMP、PMP 和 LMP）。受伤后1-72小时内重复采集动脉和脑静脉样本。还研究了 MP 亚群、暴露组织因子 (TF) 和 P-选择素。与健康对照相比，TBI 病例中脑静脉样本中的 MP 计数（无论细胞来源如何）较高（EMP 峰值水平分别高约 7 倍、PMP 1.4 倍和 LMP 2 倍；p
The potential pathophysiological role of circulating microparticles (MPs) has been recognized in various conditions, such as cardiovascular and thrombotic diseases. Traumatic brain injury (TBI) has a complex pathophysiology that involves coagulopathy and inflammation. We investigated endothelial-, platelet-, and leukocyte-derived microparticles (EMPs, PMPs, and LMPs, respectively) in 16 patients with severe isolated TBI. Arterial and cerebrovenous samples were taken repeatedly, during 1-72 h after injury. Subpopulations of MPs, exposing tissue factor (TF) and P-selectin, were also studied. MP counts in cerebrovenous samples, irrespective of cellular origin, were higher in TBI cases, compared to healthy controls (peak levels of EMPs were approximately 7 times higher, PMPs 1.4 times higher, and LMPs 2 times higher, respectively; p