Capture of the late phase of long-term Potentiation within and across the apical and basilar dendritic compartments of CA1 pyramidal neurons: Synaptic tagging is compartment restricted
Capture of the late phase of long-term Potentiation within and across the apical and basilar dendritic compartments of CA1 pyramidal neurons: Synaptic tagging is compartment restricted
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DOI：
10.1523/jneurosci.3196-05.2006
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发表时间：
2006-01-04
影响因子：
5.3
通讯作者：
Kandel, ER
中科院分区：
文献类型：
--
作者：
Alarcon, JM;Barco, A;Kandel, ER
在啮齿动物海马区的研究表明，当阈值上刺激在一组突触中诱导出长时程增强的晚期(L-LTP)时，其他接受阈值下刺激的突触也可以表达L-LTP，这种现象通常被称为“捕获L-LTP”。由于哺乳动物海马区的锥体神经元同时具有顶端和基础树突，因此我们现在研究了以前仅在顶端树突室内描述的L-LTP的捕获是否也可以发生在基底树突室内，如果是的话，是否可以从一个树突室到另一个树突室完成捕获。我们发现，L-LTP的捕获也可以发生在基底树突室，并且使捕获成为可能的标记信号在两个树突室似乎是相同的。然而，跨隔室的捕获，在顶端和基底树突之间，遵循不同的规则，需要比在间室内捕获更强的触发刺激。这些结果表明，标签似乎是特定于一个隔室的，要么是根尖的，要么是基底的，可能需要一个额外的机制来跨隔室捕捉。
Studies in the rodent hippocampus have demonstrated that when the late phase of long-term potentiation (L-LTP) is induced in a set of synapses by suprathreshold stimulation, L-LTP can also be expressed by other synapses receiving subthreshold stimulation, a phenomenon usually referred as '' capture of L-LTP.'' Because the pyramidal neurons in the mammalian hippocampus have both apical and basal dendrites, we have now investigated whether capture of L-LTP, previously described only within the apical dendritic compartment, can also take place within the basilar dendritic compartment and, if so, whether capture can be accomplished from one dendritic compartment to the other. We found that capture of L-LTP can also occur within the basilar dendritic compartment and that the tagging signal that enables capture appears to be the same in both dendritic compartments. However, capture across compartments, between the apical and basilar dendrites, follows different rules and requires a stronger triggering stimulation than capture within a compartment. These results suggest that the tag appears specific to a compartment either apical or basilar and that an additional mechanism may be required to capture across compartments.