Novel anti-microbial host-guest complexes based on cationic β-cyclodextrin polymers and triclosan/butylparaben
Novel anti-microbial host-guest complexes based on cationic β-cyclodextrin polymers and triclosan/butylparaben
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DOI：
10.1002/marc.200700505
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发表时间：
2007-12-03
影响因子：
4.6
通讯作者：
Xiao, Huining
中科院分区：
文献类型：
--
作者：
Guan, Yong;Qian, Liying;Xiao, Huining
本文报道了新型阳离子-环糊精聚合物（CP - Ms）的制备及其与对羟基苯甲酸丁酯和三氯生的配合物。FT-IR和二维（2D） H-1-H-1梯度相关光谱（gCOSY） NMR证实抗生素可能包含在CP β CDs的亲脂腔内。CP - cd包埋后抗生素的水溶性明显提高。结果还表明，对羟基苯甲酸丁酯相对分子尺寸较小，比三氯生更容易与CP β - CDs形成配合物。由于阳离子CP β CDs包合后的靶向作用，对羟基苯甲酸丁酯的抑菌活性也得到了显著增强。而三氯生的改善效果不明显。
The preparation of novel cationic beta-cyclodextrin polymers (CP beta Ms) and its complexes with butylparaben and triclosan were reported in this paper. FT-IR and two-dimensional (2D) H-1-H-1 gradient correlated spectroscopy (gCOSY) NMR spectra confirmed that the antibiotics could be included inside the lipophilic cavities of CP beta CDs. The water solubility of the antibiotics was improved significantly after cl inclusion with CP beta CDs. The results also suggest that it was easier for butylparaben, which had relatively small molecular size, to form the complexes with CP beta CDs than triclo san. Due to the targeting effect after the inclusion with cationic CP beta CDs, the anti-microbial activity of butylparaben was also enhanced substantially. However, similar im provement was not obvious for triclosan.