Genetically Determined ABO Blood Group and its Associations With Health and Disease
Genetically Determined ABO Blood Group and its Associations With Health and Disease
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DOI：
10.1161/atvbaha.119.313658
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发表时间：
2020-03-01
影响因子：
8.7
通讯作者：
van der Harst, Pim
中科院分区：
文献类型：
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作者：
Groot, Hilde E.;Sierra, Laura E. Villegas;van der Harst, Pim
目的：为了确定与ABO血型系统的表型谱，使用ABO血型system.Approach和结果的遗传决定因素：我们评估了41个健康和疾病的结果的风险，和36个线性性状与ABO血型系统在英国生物库队列。共有406755名无关个体被纳入本研究。基于先前在ABO基因中建立的单核苷酸多态性rs 8176746、rs 8176719的等位基因组合确定血型A、B和O。AB组因其样本量相对较小而被排除。总体而言，187 387例（46%）为男性，平均（SD）年龄为57 ± 8.1岁，中位总暴露量为64人-年（四分位距，57-70）。在406755名受试者中，182621人（44.9%）为O型血，182786人（44.9%）为A型血，41348人（10.2%）为B型血。ABO血型与11种健康和疾病结局相关（P
Objective:To determine the spectrum of phenotypes linked to the ABO blood group system, using genetic determinants of the ABO blood group system.Approach and Results:We assessed the risk of 41 health and disease outcomes, and 36 linear traits associated with the ABO blood group system in the UK Biobank cohort. A total of 406 755 unrelated individuals were included in this study. Blood groups A, B, and O were determined based on allele combinations of previously established single-nucleotide polymorphisms rs8176746, rs8176719 in the ABO gene. Group AB was excluded because of its relative small sample size. Overall, 187 387 (46%) were male with a mean (SD) age of 57 +/- 8.1 years and a median total exposure of 64 person-years (interquartile range, 57-70). Of 406 755 individuals, 182 621 (44.9%) participants had blood group O, 182 786 (44.9%) had blood group A, and 41 348 (10.2%) had blood group B. ABO blood groups were associated with 11 health and disease outcomes (P