A miniaturized device for wireless FSCV monitoring of dopamine in an ambulatory subject.
A miniaturized device for wireless FSCV monitoring of dopamine in an ambulatory subject.
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一种用于无线 FSCV 监测流动受试者多巴胺的小型设备。
DOI：
10.1109/iembs.2010.5626345
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Mohseni,Pedram
中科院分区：
文献类型：
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作者：
Roham,Masoud;Covey,DanielP;Daberkow,DavidP;Ramsson,EricS;Howard,ChristopherD;Garris,PaulA;Mohseni,Pedram
本文报道了一种小型化的无线监测装置，在一个流动的大鼠脑细胞外多巴胺水平使用快速扫描循环伏安法在碳纤维微电极。该器件包括采用0.5 μm双多晶硅三金属CMOS技术制造的神经化学记录集成电路，该集成电路与一些用于电源产生、偏置和芯片编程的外部元件一起组装和封装在微型刚柔结合基板上。该设备从一个单一的3-V电池，重2.3克（包括电池），并在植入成功地捕捉电和非电诱发多巴胺神经传递的尾壳核区域的一个走动大鼠的前脑的精神兴奋剂安非他明的影响。
This paper reports on a miniaturized device for wireless monitoring of extracellular dopamine levels in the brain of an ambulatory rat using fast-scan cyclic voltammetry at a carbon-fiber microelectrode. The device comprises integrated circuitry for neurochemical recording fabricated in 0.5-μm double-poly triple-metal CMOS technology, which is assembled and packaged on a miniature rigid-flex substrate together with a few external components for supply generation, biasing, and chip programming. The device operates from a single 3-V battery, weighs 2.3 g (including the battery), and upon implantation successfully captures the effects of the psychostimulant amphetamine on electrically and non-electrically evoked dopamine neurotransmission in the caudateputamen region of an ambulatory rat's forebrain.