Reemergence of Enterovirus 71 in 2008 in Taiwan: Dynamics of Genetic and Antigenic Evolution from 1998 to 2008
Reemergence of Enterovirus 71 in 2008 in Taiwan: Dynamics of Genetic and Antigenic Evolution from 1998 to 2008
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DOI：
10.1128/jcm.00630-09
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发表时间：
2009-11-01
影响因子：
9.4
通讯作者：
Wang, Jen-Ren
中科院分区：
文献类型：
--
作者：
Huang, Sheng-Wen;Hsu, Yun-Wei;Wang, Jen-Ren
近年来，肠道病毒71型（EV71）已成为亚太地区多起手足口病暴发的原因，并伴有严重的神经系统并发症。 2008年，B5基因型EV71在台湾再次出现，导致台湾发生11年来最大规模的EV71疫情。系统发育分析表明，1986 年至 2008 年间，从 B 到 C 或从 C 到 B 的显性基因型变化至少发生了 3 次。此外，通过中和试验对 EV71 进行抗原制图，结果显示重新出现的 EV71 基因型 B5 毒株形成了一个独立的簇，其抗原性与 B4 和 C 基因型不同。此外，对这一时期在台湾传播的EV71全长基因组序列的分析表明，发生了血清型内和血清型间重组。因此，建议对 EV71 进行持续监测，包括监测基因进化和抗原变化，这可能有助于 EV71 疫苗的开发。
In recent years, enterovirus 71 (EV71) has been a cause of numerous outbreaks of hand-foot-and-mouth disease, with severe neurological complications in the Asia-Pacific region. The reemergence in Taiwan of EV71 genotype B5 in 2008 resulted in the largest outbreak of EV71 in Taiwan in the past 11 years. Phylogenetic analyses indicated that dominant genotype changes from B to C or C to B occurred at least three times between 1986 and 2008. Furthermore, antigenic cartography of EV71 by using neutralization tests revealed that the reemerging EV71 genotype B5 strains formed a separate cluster which was antigenically distinct from the B4 and C genotypes. Moreover, analyses of full-length genomic sequences of EV71 circulating in Taiwan during this period showed the occurrence of intra-and interserotypic recombination. Therefore, continuous surveillance of EV71 including the monitoring of genetic evolution and antigenic changes is recommended and may contribute to the development of a vaccine for EV71.