Menthol application on healthy and inflamed goat udders changes antimicrobial components in milk
Menthol application on healthy and inflamed goat udders changes antimicrobial components in milk
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DOI：
10.1111/asj.13832
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发表时间：
2023-01-01
影响因子：
2
通讯作者：
Isobe，Naoki
中科院分区：
文献类型：
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作者：
Ohno，Ruri;Suzuki，Naoki;Isobe，Naoki
患有乳房炎的乳腺通常用抗生素结合乳房皮肤上的抗炎药物进行治疗。薄荷醇是一种抗炎药物。本研究的目的是探讨山羊乳房表面涂抹薄荷醇对牛奶中抗菌成分产生的影响。山羊(5只柴羊和11只托卡拉山羊)在健康和炎症条件下对乳房涂抹薄荷脑。乳房内注入脂多糖以诱导乳房发炎。采集乳样，测定体细胞数(SCC)、钠离子(Na+)、抗菌成分和细胞因子浓度。在健康乳房中，薄荷醇的应用增加了抗菌成分(S100A7和S100A8)的浓度，但在对照中没有。在炎症的乳房中，薄荷醇组的抗菌成分(乳铁蛋白、S100A7和S100A8)和炎症细胞因子(IL-1β)浓度高于对照组。这些结果表明，在健康和炎症条件下，在乳房上应用薄荷醇可以增加乳腺中抗菌成分的浓度。
Mammary glands with mastitis are usually treated with antibiotics in combination with anti‐inflammatory drug application on the udder skin. Menthol is an anti‐inflammatory drug. The aim of the present study was to investigate the effect of surface application of menthol on goat udders on the production of antimicrobial components in milk. Goats (5 Shiba and 11 Tokara goats) were subjected to menthol application to the udder under both healthy and inflammatory conditions. An intramammary infusion of lipopolysaccharides was carried out to induce inflammatory conditions in the udder. Milk samples were collected to determine somatic cell count (SCC) and sodium ion (Na+), antimicrobial component and cytokine concentrations. In healthy udders, menthol application increased the concentration of antimicrobial components (S100A7 and S100A8), but not in the control. In the inflamed udder, antimicrobial component (lactoferrin, S100A7, and S100A8) and inflammatory cytokine (IL‐1β) concentrations were higher in the menthol group than in the control group. These results suggest that menthol application on udders augments the antimicrobial component concentration in the mammary gland under both healthy and inflammatory conditions.