Brain Mapping and Synapse Quantification In vivo: It's Time to Imaging
Brain Mapping and Synapse Quantification In vivo: It's Time to Imaging
复制标题
体内脑图谱和突触量化：是时候进行成像了
作者：
Á. Acebes
今年夏天，有两份报纸给我们带来了令人兴奋的消息。在第一项研究中，Glasser及其同事使用神经解剖学方法并采用多模态磁共振图像（MRI），能够在健康年轻成人中定义每个大脑半球的180个区域，考虑皮质结构，功能，连接和地形（Glasser et al.，2016年a）。这项研究提供了关于人类大脑皮层神经解剖学的更高精度，更有趣的是，为未来评估与发育，衰老和疾病相关的个体差异铺平了道路。在第二项研究中，Finnema和合作者报道了使用突触囊泡糖蛋白放射性配体与正电子发射断层扫描（PET）组合来量化活人脑中的突触密度（Finnema et al.，2016年）。值得注意的是，进行体内突触定量的可能性代表了诊断突触变化和突触丧失的有力工具，突触变化和突触丧失是与许多脑疾病直接相关的早期特征。在这篇观点论文中，我将对这些文章进行评估，将它们与该领域的其他方法进行比较，并旨在预测未来的研究方向。
Two papers have rattled our summer this year, bringing us exciting news to the field. In the first one, Glasser and colleagues, using a neuroanatomical approach and employing multimodal magnetic resonance images (MRI), were able to define 180 areas per brain hemisphere considering cortical architecture, functionality, connectivity, and topography in healthy young adults (Glasser et al., 2016a). This study provides higher precision about human cerebral cortex neuroanatomy and, more interestingly, paves the way to future assessments of individual variations related to development, aging, and diseases. In the second one, Finnema and collaborators reported the use of a synaptic vesicle glycoprotein radioligand combined with positron emission tomography (PET) to quantify synaptic density in living human brains (Finnema et al., 2016). Remarkably, the possibility to perform in vivo synaptic quantifications represents a powerful tool in the diagnosis of synaptic changes and synapse loss which are early features directly associated with numerous brain disorders. In this Opinion paper, I will contribute an evaluation of these articles, comparing them with alternative approaches in the field and aiming to foresee future research directions.
影响因子：
14.5
作者：
Robinson, John L.;Molina-Porcel, Laura;Trojanowski, John Q.
通讯作者：
Trojanowski, John Q.