THYROARYTENOID MUSCLE-ACTIVITY DURING HYPOXIA, HYPERCAPNIA, AND VOLUNTARY HYPERVENTILATION IN HUMANS
THYROARYTENOID MUSCLE-ACTIVITY DURING HYPOXIA, HYPERCAPNIA, AND VOLUNTARY HYPERVENTILATION IN HUMANS
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DOI：
10.1152/jappl.1990.69.1.268
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发表时间：
1990-07-01
影响因子：
3.3
通讯作者：
VILLEPONTEAUX, RD
中科院分区：
文献类型：
--
作者：
INSALACO, G;KUNA, ST;VILLEPONTEAUX, RD
在进行性等颅压低氧和高氧性高二氧化碳状态下，记录了9例正常成人的声带内收肌--甲状旁肌的肌内肌电活动。9名受试者中有4名还进行了自愿性等颅压过度换气。在安静的室内空气呼吸期间，TA在呼气时表现出阶段性活动，在整个呼吸周期中经常表现为紧张性活动。时相和紧张性TA活性均随低氧或高碳酸血症的增加而逐渐降低。随着化学刺激的增加，紧张性活性的下降似乎比相性活性下降得更快。在可比的潮气量增量下，低氧时相TA活性的相对下降似乎比高碳酸血症时更大。在自主等张过度换气期间，TA时相活动减少，紧张性活动无明显变化。在潮气量约为基线的两倍时，高碳酸血症和自主过度换气期间TA活性的相对下降相似，尽管潮气量较高时有差异。这一结果，再加上最近在人类身上关于声带外展肌--环鳗后肌的发现，表明声带的位置不仅取决于安静呼吸时反作用力的净平衡，也取决于非自愿和自愿呼吸过多时的净平衡。
Intramuscular electromyographic activity of the thyroarytenoid (TA) muscle, a vocal cord adductor, was recorded in nine normal adult humans during progressive isocapnic hypoxia and hyperoxic hypercapnia. Four of the nine subjects also performed voluntary isocapnic hyperventilation. During quiet breathing of room air, the TA exhibitied phasic activity in expiration and often tonic activity throughout the respiratory cycle. Both phasic and tonic TA activity progressively decreased with either increasing hypoxia or hypercapnia. Tonic activity appeared to decrease more rapidly than phasic activity with increasing chemical stimulation. At comparable tidal volume increments, the relative decrease in phasic TA activity appeared to be greater under hypoxic than under hypercapnic conditions. During voluntary isocapnic hyperventilation, phasic TA activity decreased without significant change in tonic activity. At tidal volumes approximately double those of baseline, the relative decrease in TA activity was similar during both hypercapnia and voluntary hyperventilation, although differences appeared at higher tidal volumes. The results, in combination with recent findings in humans regarding the posterior cricoarytenoid muscle, a vocal cord abductor, suggest that vocal cord position is dependent on the net balance of counteracting forces not only during quiet breathing but also during involuntary and voluntary hyperpnea.