Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps.
Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps.
复制标题
未成熟的成年神经元重塑 CA3 空间图的独特潜力。
DOI：
10.1016/j.celrep.2023.113086
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发表时间：
2023
期刊：
影响因子：
8.8
通讯作者：
Kropff,Emilio
中科院分区：
文献类型：
--
作者：
Mugnaini,Matías;Trinchero,MarielaF;Schinder,AlejandroF;Piatti,VerónicaC;Kropff,Emilio
哺乳动物海马回路通过成年神经发生进行广泛的重塑。虽然这一过程已被广泛研究，但成年颗粒细胞（aGCs）对海马空间操作的具体贡献仍然未知。在这里，我们表明，在自由觅食小鼠中4周龄（年轻）aGCs的光遗传学激活产生了近端CA3中空间图的不可逆重构，同时很少引起神经活动。在随后的几天中刺激相同的神经元群以增加的功效招募CA3神经元，但未能诱导进一步的重新映射。相比之下，刺激8周龄（成熟）aGC可以可靠地激活CA3细胞，但不产生空间图的改变。我们的研究结果揭示了年轻的aGCs在重塑CA3表达中的独特作用，这种潜力可以随着成熟而耗尽并丧失。这种能力可以有助于生成支持模式分离的正交化下游码。
Mammalian hippocampal circuits undergo extensive remodeling through adult neurogenesis. While this process has been widely studied, the specific contribution of adult-born granule cells (aGCs) to spatial operations in the hippocampus remains unknown. Here, we show that optogenetic activation of 4-week-old (young) aGCs in free-foraging mice produces a non-reversible reconfiguration of spatial maps in proximal CA3 while rarely evoking neural activity. Stimulation of the same neuronal cohort on subsequent days recruits CA3 neurons with increased efficacy but fails to induce further remapping. In contrast, stimulation of 8-week-old (mature) aGCs can reliably activate CA3 cells but produces no alterations in spatial maps. Our results reveal a unique role of young aGCs in remodeling CA3 representations, a potential that can be depleted and is lost with maturation. This ability could contribute to generate orthogonalized downstream codes supporting pattern separation.