Convergent selection of a WD40 protein that enhances grain yield in maize and rice
Convergent selection of a WD40 protein that enhances grain yield in maize and rice
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提高玉米和水稻籽粒产量的WD40蛋白的趋同选择
DOI：
10.1126/science.abg7985
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发表时间：
2022-03-25
期刊：
影响因子：
56.9
通讯作者：
Yang, Xiaohong
中科院分区：
文献类型：
--
作者：
Chen, Wenkang;Chen, Lu;Yang, Xiaohong
更好地理解作物间趋同选择的程度可以大大改善育种计划。我们发现，数量性状基因座KRN2在玉米和水稻直系同源，OsKRN2，经历了趋同选择。这些直系同源物编码WD 40蛋白，并与未知功能的基因DUF1644相互作用，以负调控两种作物的籽粒数量。敲除玉米中的KRN 2或水稻中的OsKRN 2分别使谷粒产量增加了类似于10%和类似于8%，而在其他农艺性状中没有明显的权衡。此外，全基因组扫描确定了490对在玉米和水稻进化过程中经历趋同选择的直向同源基因，这些基因富集了两条共享的分子途径。KRN2与其他聚合选择的基因一起，为未来的作物改良提供了一个很好的目标。
A better understanding of the extent of convergent selection among crops could greatly improve breeding programs. We found that the quantitative trait locus KRN2 in maize and its rice ortholog, OsKRN2, experienced convergent selection. These orthologs encode WD40 proteins and interact with a gene of unknown function, DUF1644, to negatively regulate grain number in both crops. Knockout of KRN2 in maize or OsKRN2 in rice increased grain yield by similar to 10% and similar to 8%, respectively, with no apparent trade-offs in other agronomic traits. Furthermore, genome-wide scans identified 490 pairs of orthologous genes that underwent convergent selection during maize and rice evolution, and these were enriched for two shared molecular pathways. KRN2, together with other convergently selected genes, provides an excellent target for future crop improvement.