Quiescent-interval single-shot unenhanced magnetic resonance angiography of peripheral vascular disease: Technical considerations and clinical feasibility.
Quiescent-interval single-shot unenhanced magnetic resonance angiography of peripheral vascular disease: Technical considerations and clinical feasibility.
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DOI：
10.1002/mrm.22287
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发表时间：
2010-04
影响因子：
3.3
通讯作者：
Koktzoglou, Ioannis
中科院分区：
文献类型：
--
作者：
Edelman, Robert R.;Sheehan, John J.;Dunkle, Eugene;Schindler, Nancy;Carr, James;Koktzoglou, Ioannis
关键词：
我们进行了技术优化，随后进行了静息间期单次激发MR血管造影用于外周血管疾病的初步临床研究。静止间隔单次激发MR血管造影使用改良的心电图（ECG）触发、脂肪抑制、二维、平衡稳态、自由进动脉冲序列采集数据，该序列结合了切片选择性饱和和静止间隔，以最大限度地增强流入血液。在1.5 T下优化后，使用对比增强MR血管造影作为参考标准，在外周血管疾病患者中进行了初步研究。优化的序列使用228 ms的静止间隔、稳态磁化的α/2催化、以及平行加速因子为2的中心到外部分傅立叶采集。内插前，沿切片方向的空间分辨率为2- 3 mm沿着，平面内的空间分辨率为0.7- 1 mm。排除支架动脉段，静息间期单次激发MR血管造影对动脉狭窄大于50%或闭塞的敏感性、特异性、阳性和阴性预测值分别为92.2%、94.9%、83.9%和97.7%。静止间隔单次激发磁共振血管造影提供了强大的描绘正常外周动脉解剖和外周血管疾病在不到10分钟，而不需要定制的技术，为个别患者。此外，尽管存在呼吸和肠运动，该技术在骨盆区域提供一致的图像质量。
We performed technical optimization followed by a pilot clinical study of quiescent-interval single-shot MR angiography for peripheral vascular disease. Quiescent-interval single-shot MR angiography acquires data using a modified electrocardiographic (ECG)-triggered, fat suppressed, two-dimensional, balanced steady-state, free precession pulse sequence incorporating slice-selective saturation and a quiescent interval for maximal enhancement of inflowing blood. Following optimization at 1.5 T, a pilot study was performed in patients with peripheral vascular disease, using contrast-enhanced MR angiography as the reference standard. The optimized sequence used a quiescent interval of 228 ms, α/2 catalyzation of the steady-state magnetization, and center-to-out partial Fourier acquisition with parallel acceleration factor of 2. Spatial resolution was 2–3mm along the slice direction and 0.7–1mm in-plane before interpolation. Excluding stented arterial segments, the sensitivity, specificity, and positive and negative predictive values of quiescent-interval single-shot MR angiography for arterial narrowing greater than 50% or occlusion were 92.2%, 94.9%, 83.9%, and 97.7%, respectively. Quiescent-interval single-shot MR angiography provided robust depiction of normal peripheral arterial anatomy and peripheral vascular disease in less than 10 min, without the need to tailor the technique for individual patients. Moreover, the technique provides consistent image quality in the pelvic region despite the presence of respiratory and bowel motion.
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