STRUCTURAL MODEL FOR CHOLESTEROL-PHOSPHATIDYLCHOLINE COMPLEXES IN BILAYER MEMBRANES
STRUCTURAL MODEL FOR CHOLESTEROL-PHOSPHATIDYLCHOLINE COMPLEXES IN BILAYER MEMBRANES
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DOI：
10.1007/bf02533637
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发表时间：
1977-01-01
期刊：
影响因子：
1.9
通讯作者：
HUANG, CH
中科院分区：
文献类型：
--
作者：
HUANG, CH
基于磷脂和胆固醇分子的结构性质，利用已知的胆固醇及其类似物对磷脂双层的结构和运动效应，提出了胆固醇-磷脂酰胆碱复合体的模型。在这个模型中，假设胆固醇的3β-羟基与磷脂中脂肪酰基的羰基O发生氢键作用。磷脂的饱和和不饱和脂肪酰链的一些特定构型被认为参与了与α的范德华吸引的相互作用。和测试版。类固醇核的表面。
Based on the structural properties of phospholipid and cholesterol molecules, and making use of the known structural and motional effects of cholesterol and its analogs on phospholipid bilayers, a model for the cholesterol-phosphatidylcholine complex is proposed. In this model, the 3.beta.-hydroxyl group of cholesterol is assumed to engage in H-bonding with the carbonyl O of the fatty acyl groups in phospholipids. Some specific configurations of the saturated and unsaturated fatty acyl chains of the phospholipid are suggested to participate in van der Waals attractive interactions with the .alpha. and .beta. surface of the steroid nucleus.