Iron uptake and transport across physiological barriers.
Iron uptake and transport across physiological barriers.
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DOI：
10.1007/s10534-016-9952-2
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Connor JR
中科院分区：
文献类型：
--
作者：
Duck KA;Connor JR
铁是人类发育的必需元素。它是细胞过程如氧运输、能量代谢、神经递质合成和髓鞘合成的主要需要。尽管在这些过程中起着至关重要的作用，但三价铁形式的铁也会产生有毒的活性氧。铁功能的双重性突出了保持体内铁水平严格平衡的重要性。因此，生物体已经开发出铁吸收，运输和储存的优雅机制。这篇综述将集中在生理屏障，如肠，胎盘和血脑屏障（BBB），铁必须运输的机制。关于铁在肠道和胎盘中的转运过程已经有很多报道，但关于铁在BBB中的转运机制知之甚少。在这篇综述中，我们比较了肠道和胎盘的既定途径，并描述了目前已知的BBB铁转运以及脑铁摄取如何与这些其他生理屏障的过程相关。
Iron is an essential element for human development. It is a major requirement for cellular processes such as oxygen transport, energy metabolism, neurotransmitter synthesis, and myelin synthesis. Despite its crucial role in these processes, iron in the ferric form can also produce toxic reactive oxygen species. The duality of iron’s function highlights the importance of maintaining a strict balance of iron levels in the body. As a result, organisms have developed elegant mechanisms of iron uptake, transport, and storage. This review will focus on the mechanisms that have evolved at physiological barriers, such as the intestine, the placenta, and the blood–brain barrier (BBB), where iron must be transported. Much has been written about the processes for iron transport across the intestine and the placenta, but less is known about iron transport mechanisms at the BBB. In this review, we compare the established pathways at the intestine and the placenta as well as describe what is currently known about iron transport at the BBB and how brain iron uptake correlates with processes at these other physiological barriers.