Environmental fate of the antiviral drug Tamiflu in two aquatic ecosystems
Environmental fate of the antiviral drug Tamiflu in two aquatic ecosystems
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DOI：
10.1016/j.chemosphere.2008.11.060
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发表时间：
2009-03-01
期刊：
影响因子：
8.8
通讯作者：
Olsen, Bjoern
中科院分区：
文献类型：
--
作者：
Sacca, Maria Ludovica;Accinelli, Cesare;Olsen, Bjoern
抗病毒药物达菲（磷酸奥司他韦，OP）已被世界卫生组织指定为禽流感大流行情况下的第一道防线。最近的研究表明，前药OP的活性代谢产物奥司他韦羧酸盐（OC）具有释放到水体中的潜力。本实验室研究的重点是从北方意大利，波河和威尼斯lago.Results对比的水生生态系统的地表水，OC的环境归宿的基本过程，这项研究证实了OC的潜在持久性在地表水。然而，添加5%的沉积物导致快速OC降解。有机碳在蒲河的水/沉积物中的半衰期估计为15天。在20摄氏度下培养三周后，超过8%的C-14-OC从波河和威尼斯泻湖的水/沉积物样品中以（CO2）-C-14的形式进化出来。在21天的孵育期结束时，超过65%的C-14-残留物从Po和Venice水/沉积物样品的液相中回收。OC适度保留在两个站点的粗沉积物上。在水/沉积物样品的波河和威尼斯泻湖与C-14-OC处理，超过30%的C-14残留物仍然是水萃取后三个星期的孵化。有机碳对沉积物的低亲和力表明沉积物的存在不会降低其微生物降解的生物有效性。(C)2008爱思唯尔有限公司保留所有权利。
The antiviral drug Tamiflu (Oseltamivir Phosphate, OP), has been indicated by the World Health Organization as a first-line defense in case of an avian influenza pandemic. Recent studies have demonstrated that Oseltamivir Carboxylate (OC), the active metabolite of the prodrug OP, has the potential to be released into water bodies. The present laboratory Study focused on basic processes governing the environmental fate of OC in surface water from two contrasting aquatic ecosystems of northern Italy, the River Po and the Venice lagoon.Results of this study confirmed the potential of OC to persist in surface water. However, addition of 5% of sediments resulted in rapid OC degradation. Estimated half-life of OC in water/sediment of the River Po was 15 days. After three weeks of incubation at 20 degrees C, more than 8% of C-14-OC evolved as (CO2)-C-14 from water/sediment samples of the River Po and Venice lagoon. At the end of the 21-day incubation period, more than 65% of the C-14-residues were recovered from the liquid phase of both Po and Venice water/sediment samples. OC was moderately retained onto coarse sediments from the two sites. In water/sediment samples of the River Po and Venice lagoon treated with C-14-OC, more than 30% of the C-14-residues remained water-extractable after three weeks of incubation. The low affinity of OC to sediments suggests that presence of sediments would not reduce its bioavailability to microbial degradation. (C) 2008 Elsevier Ltd. All rights reserved.