Comparative aspects of GnRH-Stimulated signal transduction in the vertebrate pituitary - Contributions from teleost model systems
Comparative aspects of GnRH-Stimulated signal transduction in the vertebrate pituitary - Contributions from teleost model systems
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DOI：
10.1016/j.mce.2017.06.002
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发表时间：
2018-03-05
影响因子：
4.1
通讯作者：
Pemberton, Joshua G.
中科院分区：
文献类型：
--
作者：
Chang, John P.;Pemberton, Joshua G.
促性腺激素释放激素（GnRH）是通过作用于垂体促性腺激素释放和合成来调节生殖的主要因子。尽管人们通常认为垂体细胞只暴露于一种 GnRH，但硬骨鱼的垂体会输送多种形式的 GnRH。有趣的是，这可能包括通常被认为是非促性腺激素的 cGnRH-II 形式。 GnRH 可以直接或间接调节其他垂体细胞类型，并且多种 GnRH 受体 (GnRHR) 也可能在垂体中表达，甚至在单个垂体细胞类型内表达。关于初级垂体细胞中天然 GnRH 亚型差异作用的文献主要来自硬骨鱼。本综述将概述脊椎动物促性腺激素以及促性腺激素外位点内发现的 GnRH-GnRHR 信号转导的多样性和复杂性，特别强调鱼类模型的比较研究。还讨论了 GnRHR 转导机制是 GnRH 同种型、功能和细胞特异性的含义。 (C) 2017 Elsevier B.V. 保留所有权利。
Gonadotropin-releasing hormone (GnRH) is a major regulator of reproduction through actions on pituitary gonadotropin release and synthesis. Although it is often thought that pituitary cells are exposed to only one GnRH, multiple GnRH forms are delivered to the pituitary of teleost fishes; interestingly this can include the cGnRH-II form usually thought to be non-hypophysiotropic. GnRHs can regulate other pituitary cell-types, both directly as well as indirectly, and multiple GnRH receptors (GnRHRs) may also be expressed in the pituitary, and even within a single pituitary cell-type. Literature on the differential actions of native GnRH isoforms in primary pituitary cells is largely derived from teleost fishes. This review will outline the diversity and complexity of GnRH-GnRHR signal transduction found within vertebrate gonadotropes as well as extra-gonadotropic sites with special emphasis on comparative studies from fish models. The implications that GnRHR transduction mechanisms are GnRH isoform-, function-, and cell-specific are also discussed. (C) 2017 Elsevier B.V. All rights reserved.