ANTICOCCIDIAL EVALUATION OF HALOFUGINONE, LASALOCID, MADURAMICIN, MONENSIN AND SALINOMYCIN
ANTICOCCIDIAL EVALUATION OF HALOFUGINONE, LASALOCID, MADURAMICIN, MONENSIN AND SALINOMYCIN
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DOI：
10.1016/0304-4017(88)90013-1
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发表时间：
1988-04-01
影响因子：
2.6
通讯作者：
CONDER, GA
中科院分区：
文献类型：
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作者：
FOLZ, SD;LEE, BL;CONDER, GA
在受控的体内和体外实验室研究中，将五种抗球虫药的活性与鸡体内的艾美耳球虫属物种进行了比较。将两种较新的有效市场进入产品（马杜霉素和卤常酮）与三种较旧的聚醚抗生素抗球虫药（莫能菌素、拉沙里菌素和盐霉素）进行了比较。饮食中的活性药物分别以 3、125、5、120 和 66 ppm 的浓度对卤常酮、拉沙里菌素、马杜霉素、莫能菌素和盐霉素进行评估。在这些水平上，所有五种药物都表现出对柔嫩艾美耳球虫、巨型艾美耳球虫、恶毒艾美耳球虫、布鲁内蒂艾美耳球虫和鹿形艾美耳球虫（体内）的显着活性。莫能菌素对柔嫩艾美球虫的效果最差，而对恶毒艾美球虫效果较差的药物之一马杜霉素对巨型艾美球虫的效果也最差。在对单一艾美耳球虫属感染的研究中，发现药物的体重增加相当。然而，在混合艾美耳球虫物种感染中，用马杜霉素治疗的禽类的体重增加明显高于用莫能菌素治疗的禽类。与体内效力不同，体外滴定表明莫能菌素最有效（在10-6 mcg ml-1时有活性），而马杜霉素和拉沙里菌素最弱（在≤10-3 mcg ml-1时无活性）。
The activities of five anticoccidials were compared against Eimeria species in/of chickens, in controlled in vivo and in vitro laboratory studies. Two more recent and potent market entries (maduramicin and halofuginone) were compared with three older polyether antibiotic anticoccidials (monensin, lasalocid and salinomycin). Halofuginone, lasalocid, maduramicin, monensin and salinomycin were evaluated at 3, 125, 5, 120 and 66 ppm, respectively, of active drug in the diets. At these levels, all five drugs demonstrated significant activity against Eimeria tenella, E. maxima, E. necatrix, E. brunetti and E. acervulina (in vivo). Monensin was least effective against E. tenella, and one of the lesser efficacious drugs against E. necatrix, maduramicin, was least effective against E. maxima. In studies of single Eimeria species infections, comparable weight gains were noted for the drugs. In the mixed Eimeria species infections, however, birds treated with maduramicin had significantly higher weight gains than did birds medicated with monensin. Unlike in vivo potencies, titration in vitro indicated that monensin was most potent (active at 10-6 mcg ml-1), and maduramicin and lasalocid least potent (inactive at .ltoreq. 10-3 mcg ml-1).