Alcohol intake, type of beverage, and risk of breast cancer in pre- and postmenopausal women
Alcohol intake, type of beverage, and risk of breast cancer in pre- and postmenopausal women
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DOI：
10.1097/01.alc.0000130812.85638.e1
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发表时间：
2004-07-01
影响因子：
3.2
通讯作者：
Gronbæk, M
中科院分区：
文献类型：
--
作者：
Petri, AL;Tjonneland, A;Gronbæk, M
背景资料：大多数饮酒与乳腺癌之间的关系的研究表明，适度增加的风险，虽然结果仍然是contradiction.Methods：这个前瞻性的人群为基础的队列研究的目的是评估酒精摄入量和类型的饮料（啤酒，葡萄酒，或烈酒）对乳腺癌的风险与绝经状态的影响。在13，074名年龄在20岁至91岁之间的女性中，我们研究了乳腺癌风险，总酒精摄入量和酒精类型与绝经状态之间的关系。这些妇女被归类为绝经前或绝经后在小于70岁或70岁或以上。结果：在随访期间，76绝经前和397绝经后妇女乳腺癌。每周饮酒超过27杯的绝经前妇女与轻度饮酒者相比，患乳腺癌的相对风险为3.49（95%置信区间为1.36-8.99）（p = 0.011），而低摄入量类别的风险没有差异。绝经前妇女患乳腺癌的风险增加与饮酒类型无关。年龄超过70岁的绝经后妇女，每周饮酒超过6杯，患乳腺癌的相对风险为2.43（95%置信限，1.41-4.20）与每周饮用酒精饮料少于一杯的女性相比，结论：每周饮酒超过27杯会增加绝经前妇女患乳腺癌的风险，与饮酒类型无关。对于绝经后女性来说，每周摄入超过六杯烈酒会增加患乳腺癌的风险。
Background: Most studies of the relation between alcohol consumption and breast cancer have shown a modestly increased risk, although the results are still conflicting.Methods: The aim of this prospective population-based cohort study was to assess the influence of alcohol intake and type of beverage (beer, wine, or spirits) on breast cancer risk in relation to menopausal status. Among 13,074 women aged 20 to 91 years, we examined the relationship between breast cancer risk, total alcohol intake, and type of alcohol in relation to menopausal status. The women were classified as premenopausal or as postmenopausal at younger than 70 years or 70 years or more.Results: During follow-up, 76 premenopausal and 397 postmenopausal women developed breast cancer. Premenopausal women who had an intake of more than 27 drinks per week had a relative risk of breast cancer of 3.49 (95% confidence limits, 1.36-8.99) compared with light drinkers (p = 0.011), whereas there were no differences in risk in the lower-intake categories. The increased risk of breast cancer among premenopausal women was independent of the type of alcohol. Postmenopausal women older than 70 years of age who had an intake of more than six drinks per week of spirits had a relative risk of breast cancer of 2.43 (95% confidence limits, 1.41-4.20) compared with women who consumed less than one drink of spirits per week (p = 0.0014).Conclusions: Total alcohol intake of more than 27 drinks per week increases breast cancer risk in premenopausal women independently of the type of alcohol. Among postmenopausal women, an intake of spirits of more than six drinks per week increases breast cancer risk.