An assessment of the exposure of Americans to perfluorooctane sulfonate: A comparison of estimated intake with values inferred from NHANES data
An assessment of the exposure of Americans to perfluorooctane sulfonate: A comparison of estimated intake with values inferred from NHANES data
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DOI：
10.1038/jes.2009.73
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发表时间：
2011-03-01
影响因子：
4.5
通讯作者：
Lorber, Matthew
中科院分区：
文献类型：
--
作者：
Egeghy, Peter P.;Lorber, Matthew
为了更好地了解人类对全氟化合物（PFCs）的暴露，演示了一个模型，该模型从摄入量和身体负担的角度评估全氟辛烷磺酸（PFOS）及其前体的暴露，并将两者与一个简单的药代动力学（PK）模型相结合。在“典型”和“受污染”情景下模拟了幼儿和成人的接触途径。还使用一阶单室PK模型，根据国家健康和营养检查调查报告的全氟辛烷磺酸血清浓度估算了一系列摄入量。全氟辛烷磺酸的总摄入量（所有途径的中位数之和）估计为：在典型情景和受污染情景下，成人分别为160和2，200纳克/天，儿童分别为50和640纳克/天。食物摄入似乎是一般人群的主要接触途径。对于儿童来说，粉尘摄入的贡献几乎与食物摄入一样大。途径特异性贡献跨越几个数量级，并表现出相当大的重叠。药代动力学模型表明，成年人的全氟辛烷磺酸摄入量集中趋势在1.6至24.2纳克/千克体重/天之间，基于前瞻性的摄入量估计值也在这一范围内。有利的比较报告之间的前瞻性建模和反计算的范围内的摄入量预测借给有效性所提出的框架。Journal of Exposure Science and Environmental Epidemiology（2011）21，150-168; doi：10.1038/jes.2009.73; 2010年2月10日在线发表
To better understand human exposure to perfluorinated compounds (PFCs), a model that assesses exposure to perfluorooctane sulfonate (PFOS) and its precursors from both an intake and a body burden perspective and combines the two with a simple pharmacokinetic (PK) model is demonstrated. Exposure pathways were modeled under "typical" and "contaminated" scenarios, for young children and adults. A range of intakes was also estimated from serum concentrations of PFOS reported in the National Health and Nutrition Examination Survey (NHANES) using a first-order 1-compartment PK model. Total PFOS intakes (medians summed over all pathways) were estimated as: 160 and 2200 ng/day for adults and 50 and 640 ng/day for children under typical and contaminated scenarios, respectively. Food ingestion appears to be the primary route of exposure in the general population. For children, the contribution from dust ingestion is nearly as great as from food ingestion. Pathway-specific contributions span several orders of magnitude and exhibit considerable overlap. PK modeling suggests central tendency PFOS intakes for adults range between 1.6 and 24.2 ng/kg-bw/day, and the forward-based intake estimates are within this range. The favorable comparison reported between the forward-modeled and the back-calculated range of intake predictions lends validity to the proposed framework. Journal of Exposure Science and Environmental Epidemiology (2011) 21, 150-168; doi:10.1038/jes.2009.73; published online 10 February 2010