Are transporter associated with antigen processing (TAP) and tapasin class I MHC chaperones?
Are transporter associated with antigen processing (TAP) and tapasin class I MHC chaperones?
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DOI：
10.4049/jimmunol.158.2.541
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发表时间：
1997-01
影响因子：
4.4
通讯作者：
J. Solheim;B. Carreno;T. Hansen
中科院分区：
文献类型：
--
作者：
J. Solheim;B. Carreno;T. Hansen
I类MHC重链与内质网中的许多蛋白质相关，包括TAP、钙连接蛋白、钙网蛋白和新定义的tapasin分子。最近的研究已经开始解决这些蛋白质如何与I类相互作用的性质以及这些相互作用中的每一种的功能意义。我们建议在这里，TAP和tapasin是领先的候选人是高度特异性的I类分子伴侣。
Class I MHC heavy chains associate with many proteins in the endoplasmic reticulum, including TAP, calnexin, calreticulin, and the newly defined tapasin molecule. Recent studies have begun to resolve the nature of how these proteins interact with class I as well as the functional significance of each of these interactions. We propose here that TAP and tapasin are leading candidates to be highly specific chaperones for the class I molecule.