Intestinal enzyme adaptation to normal diets of different composition.
Intestinal enzyme adaptation to normal diets of different composition.
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DOI：
10.1152/ajpgi.1980.239.6.g445
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发表时间：
1980-12
期刊：
影响因子：
--
通讯作者：
D. McCarthy;J. Nicholson;Y. S. Kim
中科院分区：
文献类型：
--
作者：
D. McCarthy;J. Nicholson;Y. S. Kim
各组大鼠被喂食等量的富含淀粉、蛋白质或脂肪的食物。7 d后，测定各组大鼠十二指肠、空肠和回肠黏膜蔗糖酶、麦芽糖酶、乳糖酶、碱性磷酸酶、l-苯丙酰甘氨酸水解酶和l-亮氨酸-l -丙酰水解酶的活性。多肽水解酶和碱性磷酸酶活性显著高于饲喂高蛋白饲料的大鼠，特别是回肠。以高淀粉饲料喂养的大鼠双糖酶最高，尤其是空肠；该日粮的肽水解酶活性最低。高脂日粮与大多数酶的中间活性有关，但双糖酶的中间活性在高脂日粮中最低。不同的大分子营养物质与肠道酶活性的适应性差异有关，这在生物学上是适当的，并且与胰腺和其他与特定食物同化有关的酶活性的类似已知变化相协调。然而，发生了其他难以解释的变化，这可能是由于对胰腺分泌或对肠细胞的代谢、生长和分化的影响。
Groups of rats were fed isocaloric amounts of diets rich in starch, protein, or fat. After 7 days, activities of sucrase, maltase, lactase, alkaline phosphatase, L-phenylalanylglycine hydrolase, and L-leucyl-L-alanyl hydrolase were measured in the duodenal, jejunal, and ileal mucosa of fed rats. Peptide hydrolase and alkaline phosphatase activities were significantly higher in rats fed high-protein diets, particularly in the ileum. Disaccharidases were highest in rats fed high-starch diets, especially in jejunum; the lowest activities of peptide hydrolase were seen with this diet. The high-fat diet was generally associated with intermediate activities of most enzymes, except disaccharidases, which were lowest on this diet. The different macromolecular nutrients were associated with adaptive differences in intestinal enzyme activities, which were biologically appropriate and coordinated with similar known changes in pancreatic and other enzyme activities concerned with assimilation of the particular food. However, other less interpretable changes occurred, which may have been due to effects on pancreatic secretion or on the metabolism, growth, and differentiation of intestinal cells.