A Coupled Lumped-Parameter and Distributed Network Model for Cerebral Pulse-Wave Hemodynamics.
A Coupled Lumped-Parameter and Distributed Network Model for Cerebral Pulse-Wave Hemodynamics.
复制标题
DOI：
10.1115/1.4031331
复制
发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Jaiyoung Ryu;Xiao Hu;S. Shadden
中科院分区：
文献类型：
--
作者：
Jaiyoung Ryu;Xiao Hu;S. Shadden
脑循环在其在广泛变化的生理条件下维持血液流向大脑的能力方面是独特的。阐明这种自动调节反应对于脑血流量（CBF）建模以及对病理条件的研究是必要的。我们讨论了一个一维（1D）的脑动脉中的血液流动的非线性模型耦合到自动调节集总参数（LP）网络。LP网络包括颅内压（ICP）、脑脊液（CSF）和皮质侧支血流模型。整体模型用于评估由于大脑中动脉（MCA）和颈总动脉（CCA）闭塞引起的CBF变化。在CCA和颈内动脉（伊卡）的速度波形检查前和后MCA闭塞。观察到明显的波形变化，由于闭塞，提供洞察脑血管痉挛监测的形态变化的速度或压力波形。还研究了通过皮质通路和交通动脉的侧支血流建模的作用。当MCA闭塞时，皮质侧支血流具有重要的代偿作用，而当CCA闭塞时，Willis环（CoW）中的交通动脉变得更加重要。为了验证该模型，进行了模拟，以重现临床试验，以评估动态自动调节功能，结果表明与已发表的测量结果一致。
The cerebral circulation is unique in its ability to maintain blood flow to the brain under widely varying physiologic conditions. Incorporating this autoregulatory response is necessary for cerebral blood flow (CBF) modeling, as well as investigations into pathological conditions. We discuss a one-dimensional (1D) nonlinear model of blood flow in the cerebral arteries coupled to autoregulatory lumped-parameter (LP) networks. The LP networks incorporate intracranial pressure (ICP), cerebrospinal fluid (CSF), and cortical collateral blood flow models. The overall model is used to evaluate changes in CBF due to occlusions in the middle cerebral artery (MCA) and common carotid artery (CCA). Velocity waveforms at the CCA and internal carotid artery (ICA) were examined prior and post MCA occlusion. Evident waveform changes due to the occlusion were observed, providing insight into cerebral vasospasm monitoring by morphological changes of the velocity or pressure waveforms. The role of modeling of collateral blood flows through cortical pathways and communicating arteries was also studied. When the MCA was occluded, the cortical collateral flow had an important compensatory role, whereas the communicating arteries in the circle of Willis (CoW) became more important when the CCA was occluded. To validate the model, simulations were conducted to reproduce a clinical test to assess dynamic autoregulatory function, and results demonstrated agreement with published measurements.