RESPONSES TO VISUAL STIMULATION AND RELATIONSHIP BETWEEN VISUAL, AUDITORY, AND SOMATOSENSORY INPUTS IN MOUSE SUPERIOR COLLICULUS
RESPONSES TO VISUAL STIMULATION AND RELATIONSHIP BETWEEN VISUAL, AUDITORY, AND SOMATOSENSORY INPUTS IN MOUSE SUPERIOR COLLICULUS
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DOI：
10.1152/jn.1975.38.3.690
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发表时间：
1975-01-01
影响因子：
2.5
通讯作者：
HUBEL, DH
中科院分区：
文献类型：
--
作者：
DRAGER, UC;HUBEL, DH
用单细胞记录和单位簇记录的方法对麻醉小鼠上丘进行了研究。视野的地形图表现与在其他哺乳动物中发现的相似，对侧视野的时间部分向后突出，而下部视野向侧面突出。在顶盖接受野的前缘，通过对侧眼记录，并侵入同侧视野达35度，这表明通过一只眼的整个视野出现在对侧上丘上。位于最靠近顶盖表面的细胞具有相对较小的感受野，平均中心直径为9度；视野大小随着深度的增加而稳步增加。对于任何形状的暗或亮的小物体缓慢地穿过感受野中心或打开或关闭一个小的静止斑点，层中占优势的细胞类型对带状和浅灰色反应最好。较大的物体或漫反射光通常效果较差。不到四分之一的表层细胞对移动的物体表现出方向选择性，其中大多数细胞倾向于向上和鼻部运动。视层和中层灰质上部的主要视觉细胞类型类似于许多其他脊椎动物所描述的新生神经元：它们具有较大的感受野，对小的暗或亮物体的向上和鼻部运动反应最好，其最佳大小与上层细胞的最佳大小相似。如果感受野的同一部分被反复刺激，就会有明显的习惯化倾向。只有极少数细胞对同侧眼有反应。在中间灰质的上部与视觉细胞混合在一起的是对躯体感觉或听觉刺激有反应的细胞。图中还可见双峰和三峰细胞。在更深的层面上，躯体感觉和听觉形式往往会占据主导地位。这两种模式没有被分成亚层，而是似乎以簇的形式排列。对躯体感觉和听觉刺激的反应很快，对重复刺激几乎没有习惯性。
The superior colliculus was studied in anesthetized mice by recording from single cells and from unit clusters. The topographic representation of the visual filed was similar to what has been found in other mammals, with the temporal part of the contralateral visual field projecting posteriorly and the inferior visual field projecting laterally. At the anterior margin of the tectum receptive fields recorded through the contralateral eye and invaded the ipsilateral visual hemifield for up to 35 degrees, suggesting that the entire visual field through one eye is represented on the contralateral superior colliculus. Cells located closest to the tectal surface had relatively small receptive fields, averaging 9 degrees in center diameter; field sizes increased steadily with depth. The prevailing cell type in the stratum zonal and superficial gray responded best to a small dark or light object of any shape moved slowly through the receptive-field center or to turning a small stationary spot on or off. Large objects or diffuse light were usually much less effective. Less than one-quarter of superficial layer cells showed directional selectivity to a moving object, the majority of these favoring up and nasal movement. The chief visual cell type in the stratum opticum and upper part of the intermediate gray resembled in the newness neurons described for many other vertebrates: they had large receptive fields and responded best to up and nasal movement of a small dark or light object, whose optimal size was similar to the optimum for upper-layer cells. If the same part of the receptive field was repeatedly stimulated there was a marked tendency to habituate. Only very few cels responded to the ipsilateral eye. Intermixed with visual cells in the upper part of the intermediate gray were cells that responded to somatosensory or auditory stimuli. Here bimodal and trimodal cells were also seen. In deeper layers somatosensory and auditory modalities tended to take over. These two modalities were not segregated into sublayers but rather seemed to be arranged in clusters. Responses to somatosensory and auditory stimuli were brisk, showing little habituation to repeated stimulation.