Novel supramolecular elastomer films based on linear carboxyl-terminated polydimethylsiloxane oligomers: preparation, characterization, biocompatibility, and application in wound dressings
Novel supramolecular elastomer films based on linear carboxyl-terminated polydimethylsiloxane oligomers: preparation, characterization, biocompatibility, and application in wound dressings
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DOI：
10.1080/09205063.2014.938977
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发表时间：
2014-08
期刊：
影响因子：
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通讯作者：
Anqiang Zhang;Wenwen Deng;Yaling Lin;Junhui Ye;Yaomin Dong;Yufeng Lei;Hongtao Chen
中科院分区：
文献类型：
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作者：
Anqiang Zhang;Wenwen Deng;Yaling Lin;Junhui Ye;Yaomin Dong;Yufeng Lei;Hongtao Chen
通过端羧基聚二甲基硅氧烷低聚物与二乙三胺和尿素的两步反应，制备了一种基于低分子量聚二甲基硅氧烷链间多个氢键结合的新型超分子弹性体（SESi），并对反应机理进行了表征。差示扫描量热法和x射线衍射分析结果表明，SESi的超分子网络结构是完全无定形的，在室温下具有类似橡胶的弹性行为。热压法制备的透明SESi膜具有良好的粘弹性、良好的吸水率、水蒸气转化率和理想的生物相容性；并且没有显示细胞毒性或皮肤刺激。这些特性使弹性体可以作为闭塞性伤口敷料。为了证明其在伤口敷料中的潜力，对3M Tegaderm™商业薄膜和SESi薄膜进行了详细的比较。SESi膜对伤口愈合效果相似，且伤口床被SESi膜覆盖，未发生明显不良反应。
A novel supramolecular elastomer (SESi) based on multiple hydrogen bond associations between low-molecular-weight polydimethylsiloxane chains was obtained through a two-step reaction of linear carboxyl-terminated polydimethylsiloxane oligomers with diethylenetriamine and urea, and the reaction mechanism was characterized. The results of differential scanning calorimetry and X-ray diffraction analyses indicated that the supramolecular network structure is completely amorphous, endowing SESi with rubber-like elastic behavior at room temperature. The transparent SESi film prepared by hot pressing displayed nice viscoelasticity, benign water absorption, water vapor transition rates, and ideal biocompatibility; and did not show cytotoxicity or skin irritation. These properties allow the elastomer to function as an occlusive wound dressing. To demonstrate its potential in wound dressings, a detailed comparison of commercial 3M Tegaderm™ film and the SESi film was conducted. The SESi film exhibited similar effects in wound healing, and the wound bed was covered by the SESi film without the occurrence of significant adverse reactions.