Increased Prevalence of Sleep-Disordered Breathing in Adults
Increased Prevalence of Sleep-Disordered Breathing in Adults
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DOI：
10.1093/aje/kws342
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发表时间：
2013-05-01
影响因子：
5
通讯作者：
Hla, Khin Mae
中科院分区：
文献类型：
--
作者：
Peppard, Paul E.;Young, Terry;Hla, Khin Mae
睡眠呼吸障碍是一种常见的疾病，具有一系列有害的后遗症。肥胖是睡眠呼吸障碍的一个重要原因，由于肥胖症的流行，以前对睡眠呼吸障碍患病率的估计需要更新。我们使用威斯康星州睡眠队列研究的数据估计了1988-1994年和2007-2010年期间美国睡眠呼吸障碍的患病率，该研究是一项正在进行的基于社区的研究，成立于1988年，参与者从威斯康星州成年人的就业人群中随机选择。共有1,520名30-70岁的参与者进行了基线多导睡眠图研究，以评估睡眠呼吸障碍的存在。参与者被邀请每隔4年重复研究。将睡眠呼吸障碍的患病率建模为年龄、性别和体重指数的函数，并将估计值外推至使用国家健康和营养检查调查数据估计的美国体重指数分布。目前中度至重度睡眠呼吸障碍的患病率估计（呼吸暂停低通气指数，以事件/小时测量，>= 15）为10%（95%置信区间（CI）：7，12），30-49岁男性; 17%（95% CI：15，21）; 30-49岁女性为3%（95% CI：2，4）; 50-70岁女性为9%（95% CI：7，11）。这些估计的流行率在过去20年中大幅增加（根据亚组的不同，相对增加14%至55%）。
Sleep-disordered breathing is a common disorder with a range of harmful sequelae. Obesity is a strong causal factor for sleep-disordered breathing, and because of the ongoing obesity epidemic, previous estimates of sleep-disordered breathing prevalence require updating. We estimated the prevalence of sleep-disordered breathing in the United States for the periods of 1988-1994 and 2007-2010 using data from the Wisconsin Sleep Cohort Study, an ongoing community-based study that was established in 1988 with participants randomly selected from an employed population of Wisconsin adults. A total of 1,520 participants who were 30-70 years of age had baseline polysomnography studies to assess the presence of sleep-disordered breathing. Participants were invited for repeat studies at 4-year intervals. The prevalence of sleep-disordered breathing was modeled as a function of age, sex, and body mass index, and estimates were extrapolated to US body mass index distributions estimated using data from the National Health and Nutrition Examination Survey. The current prevalence estimates of moderate to severe sleep-disordered breathing (apnea-hypopnea index, measured as events/hour, >= 15) are 10% (95% confidence interval (CI): 7, 12) among 30-49-year-old men; 17% (95% CI: 15, 21) among 50-70-year-old men; 3% (95% CI: 2, 4) among 30-49-year-old women; and 9% (95% CI: 7, 11) among 50-70 year-old women. These estimated prevalence rates represent substantial increases over the last 2 decades (relative increases of between 14% and 55% depending on the subgroup).