Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate
Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate
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DOI：
10.7554/elife.44278
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发表时间：
2019-05-07
期刊：
影响因子：
7.7
通讯作者：
Drew, Patrick J.
中科院分区：
文献类型：
--
作者：
Norwood, Jordan N.;Zhang, Qingguang;Drew, Patrick J.
脑脊液（CSF）流经大脑，传输化学信号并清除废物。脑中CSF的产生通过CSF的恒定流出来平衡，其解剖学基础知之甚少。在这里，我们的特点是解剖和生理功能的脑脊液流出途径沿着嗅觉神经通过筛板，并进入鼻上皮细胞。嗅感觉神经的化学消融大大减少了脑脊液通过筛板的流出。CSF流出量减少未引起颅内压（ICP）升高，这与CSF引流或产生模式的改变一致。我们的研究结果表明，嗅觉感觉神经元的损伤（如空气污染）可能导致CSF周转和流量的改变，为神经系统疾病提供了潜在的机制。
Cerebrospinal fluid (CSF) flows through the brain, transporting chemical signals and removing waste. CSF production in the brain is balanced by a constant outflow of CSF, the anatomical basis of which is poorly understood. Here, we characterized the anatomy and physiological function of the CSF outflow pathway along the olfactory sensory nerves through the cribriform plate, and into the nasal epithelia. Chemical ablation of olfactory sensory nerves greatly reduced outflow of CSF through the cribriform plate. The reduction in CSF outflow did not cause an increase in intracranial pressure (ICP), consistent with an alteration in the pattern of CSF drainage or production. Our results suggest that damage to olfactory sensory neurons (such as from air pollution) could contribute to altered CSF turnover and flow, providing a potential mechanism for neurological diseases.