Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure.
Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure.
复制标题
可卡乙烯预暴露后对可卡因运动激活作用的敏感性。
DOI：
10.1016/0006-8993(96)00783-4
复制
发表时间：
1996
期刊：
影响因子：
2.9
通讯作者：
Roth,RH
中科院分区：
文献类型：
--
作者：
Horger,BA;Taylor,JR;Elsworth,JD;Jatlow,PI;Roth,RH
本研究评估了可卡因在雄性Sprague-Dawley大鼠中诱导对可卡因行为激活效应的致敏的能力。预先暴露于可卡因（15或25毫克/公斤）显着增强了随后的可卡因（15毫克/公斤）的挑战注射的自发激活作用。此外，几种剂量（10、15或25 mg/kg）的急性腹膜内给药证实了先前的报告，即可卡因在脑和血浆中的生物利用度相对于可卡因有所增加。这些数据进行了讨论，在以前的工作中，可卡因诱导的自发活动的显着增强没有观察到可卡因预暴露。
The present study assessed the ability of cocaethylene to induce sensitization to the behavioral activating effects of cocaine in the male Sprague-Dawley rat. Preexposure to cocaethylene (15 or 25 mg/kg) significantly enhanced the locomotor activating effects of a subsequent cocaine (15 mg/kg) challenge injection. In addition, acute intraperitoneal administration at several doses (10, 15, or 25 mg/kg) confirmed previous reports of increased bioavailability of cocaine in brain and plasma relative to cocaethylene. These data are discussed in terms of previous work in which a significant augmentation of cocaine-induced locomotor activity was not observed following cocaethylene preexposure.